LORISTA - UMARNIN DON AMFANI, FARASHI, SAKE DUBAWA DA KUMA ALAMUN ANALOGUES

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Lorista magani ne daga rukunin masu adawar angiotensin-2 masu adawa da ita (masu fafatawa). Karshen yana nufin hormones. Yana ba da gudummawa ga vasoconstriction, samar da aldosterone (hormone adrenal) da haɓakar hawan jini. Angiotensin wani bangare ne na tsarin renin-angiotensin.

Wasanni

Code Lorista anatomical da warkewa sunadarai rarrabuwa C09CA01.

Lorista magani ne daga ƙungiyar antagonists wanda ke inganta vasoconstriction, samar da glandon adrenal glandon da karuwa a hawan jini.

Saki siffofin da abun da ke ciki

Ana sayar da maganin ta hanyar allunan da aka rufe fim. Potsalensa losartan shine mai amfani da wannan magani. Abunda ke cikin kwamfutar 1 shine 12.5 MG, 25 MG, 50 MG ko 100 MG.

Abun da ya shafi magungunan ya hada da cellactose, sitaci, hypromellose fim da sauran abubuwan da aka gyara.

Allunan suna convex a bangarorin biyu, masu launin shuɗi ko fari a launi (a allurai 50 da 100 MG) da zagaye.

Hanyar aikin

Magungunan yana da zaɓi. Yana shafar masu karɓar AT1 a cikin kodan, ƙoshin lafiya, zuciya, tasoshin jini, hanta da glandar adrenal, wanda ke haifar da raguwa a cikin tasirin hauhawar jini na angiotensin-2.

Magungunan yana da tasirin magunguna masu zuwa:

Yana ƙara yin renin aiki.
Yana rage yawan haɗarin aldosterone.
Yana hana vasoconstriction (vasoconstriction).
Ba ya tasiri da samuwar bradykinin.
Yana rage juriyar jijiyoyin jini.
Na haɓaka diureis (fitowar ƙwayar ruwa mai yawa a cikin fitsari ta hanyar tace plasma jini).
Yana rage karfin jini (galibi a cikin da'irar hanji). Yana rage hawan jini da na ciki. Ana lura da matsakaicin raguwar matsin lamba 5-6 bayan shan allunan. Wani amfani mai mahimmanci game da miyagun ƙwayoyi shine rashi ciwo na cirewa.
Yana rage damuwa a zuciya.
Yana hana hauhawar jini a zuciya.
Resistanceara yawan juriya ga ɗan adam. Wannan yana da mahimmanci ga marasa lafiya da raunin zuciya.
Ba ya canza raunin zuciya.

Lorista yana shafar masu karɓar AT1 a cikin kodan, tsokoki mai laushi, zuciya, jijiyoyin jini, hanta, da glandar adrenal.

Magungunan ya sa baki tare da aiwatar da vasoconstriction.

Magungunan na taimakawa wajen cire zubar ruwa mai yawa a cikin fitsari ta hanyar tace plasma jini.

Pharmacokinetics

Dangane da karatun likitanci, yawan shan Lorista a cikin ciki da karamin hanji yana faruwa da sauri.

Cin abinci ba ya shafar taro na mai aiki metabolite. A bioavailability na miyagun ƙwayoyi ya kusan 33%. Sau ɗaya a cikin jini, losartan yana haɗuwa tare da albumin kuma ana rarraba shi ko'ina cikin gabobin. Tare da hanyar da miyagun ƙwayoyi ta hanyar hanta, metabolism dinsa yana faruwa.

Rabin rabin Lorista shine awa 2. Mafi yawan magunguna an goge su da bile. Wani ɓangare na losartan yana fitar da kodan tare da fitsari. Wani fasali na Lorista shine cewa kwayar ba ta shiga kwakwalwa.

Cin abinci ba ya tasiri da haɗuwa da abubuwan da ke tattare da ƙwayoyi.

Abinda ya taimaka

An nuna maganin don:

hauhawar jini daga asali daban-daban;
hagu ventricular hagu (ventricle hagu);
CHF;
proteinuria tare da nau'in ciwon sukari na 2 (magani yana rage hadarin nephropathy da gazawar koda).

A wani matsin lamba don ɗauka

Shan maganin yana barata tare da karfin jini na 140/90 mm Hg. kuma sama. Ana amfani da wannan magani mafi yawan lokuta idan akwai rashin ƙarfi ko rashin iya amfani da alluran ACE.

Shan maganin Lorista yana barata tare da karfin jini na 140/90 mm Hg. kuma sama.

Contraindications

Kada a sanya Lorist tare da:

karancin jini;
yawan wuce haddi a cikin jini;
rashin haƙuri a cikin abubuwan da ke cikin miyagun ƙwayoyi;
haihuwar yaro da lactation;
rashin ruwa a jiki.
malabsorption na galactose ko glucose;
rashin haƙuri ga madara sukari.

Ba a gudanar da cikakken karatun asibiti game da tasirin magani a jikin yaran ba, saboda haka an sanya maganin ne kawai ga manya. Idan ana batun daidaiton ma'aunin ruwa, na koda, tabarbarewar hanta da kuma toshewa da jijiyoyin koda, ana buƙatar taka tsantsan yayin aikin jiyya.

Yadda ake ɗauka

Ana shan maganin a baki sau 1 kowace rana kafin, lokacin ko bayan abinci. A babban matsin lamba, sashi shine 50 MG / rana. Ana iya ƙara kashi zuwa 100 MG.

Ana shan maganin a baki sau 1 kowace rana kafin, lokacin ko bayan abinci.

Haka kuma, yawan gudanarwa sau 1-2 a rana. Tun da miyagun ƙwayoyi yana da sakamako na diuretic, lokacin da ake jiyya tare da diuretics, an wajabta Lorista a cikin sashi na 25 MG, sannu a hankali yana ƙara sashi.

Dattijon, marassa lafiya a kan yanayin hemodialysis da kuma mutanen da ke fama da matsalar jujjuyawar kwayar cuta ana yin su.

A cikin CHF, kashi na farko na yau da kullun shine 12.5 MG. Sannan ya haura zuwa 50 MG / rana. Kowane mako na wata daya, ana fara ƙaruwa na farko da kashi 12.5. Lorista yana haɗuwa sau da yawa tare da wasu wakilai waɗanda ke shafar tsarin zuciya da jijiyoyin jini (diuretics, glycosides). Marasa lafiya tare da ƙara haɗarin haɗarin cerebrovascular accident Lorista suna buƙatar ɗaukar 50 mg / rana.

Shan maganin don ciwon sukari

Don rigakafin lalacewar koda a cikin marasa lafiya da nau'in ciwon sukari na 2, sashi shine 50-100 mg / rana.

Side effects

A wani ɓangare na tsarin endocrine da gabobin kirji, ba a lura da halayen da ba su dace ba.

Lokacin shan Lorista, ciwon ciki na iya faruwa.

Gastrointestinal fili

Lokacin ɗaukar Lorista, waɗannan abubuwan da ba a ke so ba suna yiwuwa:

ciwon ciki
take hakkin stool a cikin hanyar gudawa;
tashin zuciya
ciwon hakori;
bushe bakin
bloating;
amai
maƙarƙashiya
nauyi asara har zuwa anorexia;
karuwa a cikin taro na hanta enzymes na hanta a cikin jini (da wuya);
karuwar bilirubin a cikin jini.

A cikin mawuyacin hali, yayin aikin jiyya, gastritis da hepatitis na iya haɓaka.

Hematopoietic gabobin

Wani lokaci, purpura da anemia na faruwa.

Shan maganin yana iya haifar da cutar rashin jini.

Tsarin juyayi na tsakiya

A wani ɓangaren tsarin juyayi, asthenia (rage aiki, rauni), rashin bacci, ciwon kai, raunin ƙwaƙwalwar ƙwaƙwalwa, farin ciki, rashi mara nauyi a cikin nau'in paresthesia (tingling, goosebumps) ko hypesthesia, migraine, damuwa, fainting, da ciki mai yiwuwa ne. Wani lokacin neuropathy na waje da ataxia suna tasowa.

Cutar Al'aura

Lokacin ɗaukar Lorista, waɗannan nau'ikan halayen rashin lafiyan suna yiwuwa:

itching
kurji
urticaria;
Kushin rubutun Quincke.

A cikin mawuyacin hali, jijiyoyin jiki na sama yana kumbura da numfashi mai wahala.

Tasiri kan ikon sarrafa abubuwan inji

Babu wani bayani game da tasirin Lorista a kan ikon mutum na tuki mota da kayan aiki.

Babu wani bayani kan tasirin Lorista kan iyawar mutum don tuki mota.

Umarni na musamman

Lokacin kulawa da Lorista, dole ne a bi umarnin nan:

dangane da raguwar hauhawar jini, yana da farko wajibi ne a dawo da shi ko kuma a fara magani da karancin maganin;
lura da matakan halittar jini;
Kula da matakin potassium a cikin jini.

Marasa lafiya tare da nakasa aikin hanta

Tare da cirrhosis matsakaici, karuwa a cikin adadin losartan a cikin jini yana yiwuwa, sabili da haka, mutanen da ke da ilimin hanta suna buƙatar raguwa a cikin sashi na miyagun ƙwayoyi.

Marasa lafiya tare da nakasa aiki na renal

Tare da rashin isasshen aiki, ana ɗaukar Lorista da taka tsantsan. An shawarci marasa lafiya don su ba da gudummawar jini don bincike don tantance yawan ƙwayoyin nitrogen.

Lokacin amfani da Lorista, kuna buƙatar dakatar da shayarwa.

Yayin ciki da lactation

Yin amfani da miyagun ƙwayoyi yayin haihuwar yara yana ƙara haɗarin lalacewar tayi saboda tasirin Lorista akan tsarin renin-angiotensin. Lokacin amfani da Lorista, kuna buƙatar dakatar da shayarwa.

Alƙawarin Lorist ga yara

An sanya maganin a cikin yara da matasa.

Sashi a cikin tsufa

Ga mutanen da suka tsufa, kashi na farko ya dace da matsayin tsarin kulawa. Allunan ana ɗauka da safe, yamma ko yamma.

Amfani da barasa

Lokacin amfani da Lorista, yana da kyau a bar amfani da giya.

Yawan damuwa

Alamomin yawan shan ruwa sama sune:

bugun zuciya;
saukar da saukar karfin jini da cuta;
pallor na fata.

Wani lokacin bradycardia yana tasowa. A cikin irin waɗannan mutane, ƙarancin zuciya ba shi da beats / min. Taimakawa ya ƙunshi tilasta wa diureis da kuma amfani da magunguna na alamomi. Tsabtace jini ta hanyar hemodialysis bashi da tasiri.

Yin hulɗa tare da wasu kwayoyi

Rashin daidaituwa na Lorista tare da:

magungunan fluconazole;
Rifampicin;
Spironolactone;
NSAIDs;
Triamteren;
Amiloridine.

Rashin daidaituwa na Lorista tare da magunguna na tushen fluconazole.

Wani fasali na Lorista shine cewa yana haɓaka tasirin sakamako masu mahimmanci na beta-blockers, diuretics da juyayi.

Analogs

Lorista analogues na dauke da losartan sune magunguna kamar su Presartan, Lozarel, Kardomin-Sanovel, Blocktran, Lozap, Vazotens, Lozartan-Richter, Kozaar da Lozartan-Teva.

Madadin abubuwa na Lorista na iya zama magunguna masu rikitarwa. Wadannan sun hada da Lortenza, GT Blocktran, Losartan-N Canon, Lozarel Plus, Gizaar da Gizaar Forte.

Babu magani Lorista Plus. Wani hadadden shiri, Lozap AM, wanda ya ƙunshi losartan da amlodipine suma suna kan siyarwa.