Gabagamma yana cikin rukunin magungunan antiepilepti. Dalili shine gabapentin mai aiki, wanda ke da tasiri na rashin nasara. Ba kamar sauran magunguna masu tasiri iri ɗaya ba, capsules Gabagamma ba su shafar metabolism na gamma-aminobutyric acid. A cikin aikin likita, an ba da damar amfani da miyagun ƙwayoyi don amfani da marasa lafiya fiye da shekara 12 don kawar da cututtukan ɓangare, daga shekara 18 - don maganin ciwon neuropathic.
Sunan kasa da kasa mai zaman kansa
Gabapentin.
Gabagamma yana cikin rukunin magungunan antiepilepti.
ATX
N03AX12.
Saki siffofin da abun da ke ciki
Ana yin magungunan a cikin nau'i na capsules, mai rufi tare da harsashi gelatin mai wuya, don gudanar da maganin baka.
Kafurai
Rukunin magunguna sun ƙunshi 100, 300 ko 400 MG na kayan aiki na gabapentin. Kamar yadda ake amfani da ƙarin abubuwan haɗin don samar da harsashi na waje:
- talc;
- sukari madara;
- sitaci masara;
- titanium dioxide.
Dangane da sashi, ƙwayar capsules an bambanta ta launi: a gaban 100 MG na gabapentin, ƙwayar gelatin ta kasance fari, a 200 MG yana da launin rawaya saboda ɗakin da aka dogara da sinadarin baƙin ƙarfe, orange na 300 MG. A cikin capsules farar fata ne.
Ana yin magungunan a cikin nau'i na capsules, mai rufi tare da harsashi gelatin mai wuya, don gudanar da maganin baka.
Form babu shi
Ba a yin maganin ta hanyar Allunan ba.
Aikin magunguna
Tsarin sunadarai na gabapentin kusan iri ɗaya ne ga mai ba da izini ga GABA (gamma-aminobutyric acid), amma aiki mai aiki na Gabagamma yana da alaƙar magungunan. Abubuwan magani ba su yin hulɗa tare da aminalon kamar sauran magunguna (barbiturates, abubuwan da suka samo asali na GABA, Valproate) kuma basu da halayen GABA-ergic. Gabapentin ba ya shafar fashewarwa da kuma ɗaga ruwan γ-aminobutyric acid.
A cikin nazarin asibiti, an bayyana cewa abu mai aiki yana ɗaure wa matakin yanki na tashoshi na alli, sakamakon wanda ion ions mai ƙonawa ke raguwa. Bi da bi, Ca2 + yana taka rawa wajen ƙirƙirar raunin neuropathic. A cikin layi ɗaya tare da hana tashoshin alli, gabapentin ya hana ɗaukar nauyin glutamic acid zuwa cikin neurons, saboda kada mutuwar jijiya ta faru. Samun GABA yana ƙaruwa, ƙaddamar da ƙwaƙwalwar ƙwaƙwalwa na ƙungiyar monoamine yana raguwa.
Tare da gudanarwa na baka, harsashi na waje ya fara rushewa a ƙarƙashin aikin enzymes na hanji, kuma an saki gabapentin a cikin sashin kusancin ƙananan hanjin.
Pharmacokinetics
Tare da gudanarwa na baka, harsashi na waje ya fara rushewa a ƙarƙashin aikin enzymes na hanji, kuma an saki gabapentin a cikin sashin kusancin ƙananan hanjin. Ana amfani da abu mai aiki ta microvilli. Gabapentin yana shiga cikin jini, inda ya isa mafi yawan maida hankali a cikin awa 2-3. Yana da mahimmanci a tuna cewa bioavailability yana raguwa tare da kara sashi kuma ya kai kimanin 60%. Cin abinci baya tasiri cikakke da adadin ƙwayoyi.
Cire rabin rayuwa yana sanya awanni 5-7. Magungunan ya isa cikin daidaituwa daidai da kashi ɗaya. Matsayin daure na gabapentin ga ƙwayoyin plasma sun yi ƙasa kaɗan - ƙasa da 3%, don haka an rarraba magungunan a kyallen takarda a cikin wani tsari mara canzawa. Magungunan an cire shi ta amfani da tsarin urinary a asalinsa, ba tare da an samu canji a hepatocytes ba.
Abinda ya warkarwa
Magungunan yana cikin rukunin magungunan maganin kashe kashe. Ga marasa lafiya da shekarunsu suka wuce 12, an wajabta Gabagamm a matsayin wani ɓangare na maganin haɗuwa da cututtukan ɓangare, kasancewar kasancewar ko rashin jigilar halitta ta sakandare. Ga tsofaffi, allunan an wajabta su na postherpetic neuralgia da ciwo mai raɗaɗi dangane da tushen ciwon sukari mai ciwon sukari.
Ga marasa lafiya waɗanda suka girmi shekaru 12 da haihuwa, an wajabta Gabagamm a matsayin wani ɓangare na haɗuwa da jijiyoyi daga cututtukan ɓangare.
Contraindications
Ba a sanya magani ba idan akwai karuwar yiwuwar ƙwaƙƙwaran ƙwaƙƙwaran ƙwayoyin cuta zuwa abubuwan tsarin Gabagamma. Sakamakon kasancewar lactose a cikin abun da ke ciki, an sanya maganin don amfani a cikin marasa lafiya da rashi na sukari na madara da galactose, tare da rashin lactase da malabsorption na monosaccharides.
Tare da kulawa
Ba a ba da shawarar ba ko a yi taka tsantsan yayin ɗaukar marasa lafiya da cututtukan cututtukan hauka ko gazawa.
Yadda za'a dauki Gabagamma
Ana shan maganin a baka, ba tare da la'akari da abincin ba. Idan kana buƙatar soke maganin, dole ne a dakatar da amfani da Gabagamma a hankali tsawon mako guda. Magungunan ƙwayoyi tare da haɓaka sashi yana faruwa ne idan aka gaji da haƙuri, ƙarancin nauyi ko kuma a cikin yanayin mai haƙuri, gami da rauni a lokacin murmurewa bayan dasawa. A irin wannan yanayin, ya zama dole a fara da sashi na 100 MG.
An kafa tsarin kula da jiyya ta ƙwararren likita wanda ya danganta da yanayin mai haƙuri da hoton asibiti na abin da ya kamu.
| Cutar | Tsarin warkewa |
| Jin zafi na jijiyoyi a cikin marasa lafiyar manya | Adadin yau da kullun a matakin farko na farji ya kai 900 MG tare da mitar gudanarwa sau 3 a rana. Idan ya cancanta, ana iya ƙara yawan yau da kullun zuwa matsakaicin 3600 MG. An ba da shawarar fara magani ba tare da rage kashi ba daidai da tsarin da ya dace: 300 MG sau 3 a rana. A wannan yanayin, marasa lafiya tare da raunana jiki yakamata su ƙara adadin yau da kullun zuwa 900 MG na kwanaki 3 bisa ga tsarin madadin magani:
|
| M yankewa cikin mutane sama da 12 years old | An bada shawara don ɗaukar daga 900 zuwa 90000 a kowace rana. Magungunan ƙwayar cuta a ranar farko ta fara ne da maganin 900 MG, ya kasu kashi uku. Don rage haɗarin ƙwayar tsoka, tazara tsakanin ikon maganin capsule kada ta wuce sa'o'i 12. A cikin kwanakin da ke gaba na maganin, yana yiwuwa a ƙara kashi zuwa matsakaicin (3.6 g). |
Tare da ciwon sukari
Magungunan ba ya tasiri matakin sukari na plasma kuma baya canza asirin hormonal na insulin ta hanyar ƙwayoyin beta na pancreas, don haka babu buƙatar karkatar da tsarin kulawa da shawarar da aka bayar a gaban masu ciwon sukari.
Side effects
Sakamakon sakamako na sakamako a cikin mafi yawan lokuta yana faruwa tare da tsarin tsarin kwalliya da aka zaɓa ba daidai ba ko karkacewa daga shawarwarin likita. Wataƙila ci gaban zazzabi mai guba, karuwar gumi, jin zafi a yankuna daban-daban na jiki.
Daga tsoka da kashin haɗin kai
Magungunan ba su da tasiri ga tsarin musculoskeletal, amma tare da lalacewar kai tsaye ga tsarin juyayi, jin zafi a cikin tsokoki da gidajen abinci, ƙashi mai saurin ƙarfe na iya bayyana.
Hematopoietic gabobin
Tare da canji a cikin sigogi na tsarin hematopoietic, thrombocytopenic purpura na iya bayyana, tare da rauni, raguwa a cikin adadin abubuwan da aka kafa a cikin jini.
Gastrointestinal fili
Abubuwan da ba su dace ba a cikin kayan narkewa ana nuna su ta hanyar abubuwan da suka biyo baya:
- zafin epigastric;
- anorexia;
- ƙwanƙwasa, zawo, amai;
- kumburi da hanta;
- haɓaka ayyukan hepatocytic aminotransferases;
- jaundice akan asalin cutar hyperbilirubinemia;
- maganin ciwon huhu
- dyspepsia da bushewar bakin.
Tsarin juyayi na tsakiya
Tare da hanawar jijiya, yana yiwuwa:
- Dizziness
- take hakkin yanayin motsi;
- choreoathetosis;
- asarar reflexes;
- hallucinations;
- asarar iko na tunani
- rage aiki na fahimi, raunin tunani;
- paresthesia.
A cikin lokuta mafi ƙarancin yanayi, amnesia ke haɓaka, yawan tasirin mawuyacin hali yana ƙaruwa.
Daga tsarin numfashi
Wataƙila cin gaban ƙarancin numfashi, ciwon huhu. Tare da raunana rigakafi, matakai na kamuwa da cuta, cututtukan hoto ko bidiyo mai zagaya yanar gizo, cututtukan hanji, da kuma hancin hanci na iya haɓaka.
A ɓangaren fata
A lokuta na musamman, kuraje, farji na farji, erythema, itching da rashes na iya faruwa.
Daga tsarin kare jini
A cikin mafi yawan lokuta, marasa lafiya mai saurin kamuwa da cuta na iya haifar da cututtukan urinary tract, rage erections, enuresis (urinary incontinence), da kuma ƙarancin koda.
A lokuta da dama, marasa lafiyan na iya kamuwa da cututtukan urinary fili.
Daga tsarin zuciya
Wataƙila ci gaban alamun vasodilation, haɓaka ƙarancin zuciya da haɓaka hauhawar jini.
Cutar Al'aura
Idan mai haƙuri ya kasance da halayen halayen rashin lafiyan, yana yiwuwa haɓaka edema na Quincke, anaphylactic shock, angioedema, Stevens-Johnson syndrome da halayen fata.
Tasiri kan ikon sarrafa abubuwan inji
Ganin irin haɗarin mummunan halayen da ke tattare da tsarin juyayi na tsakiya (CNS) yayin lokacin maganin ƙwayar cuta, ana ba da shawarar iyakance aiki tare da haɗari ko na'urori masu haɗari, tuki mota da shiga cikin ayyukan da ke buƙatar taro da saurin halayen daga mai haƙuri.
Umarni na musamman
Duk da kasancewar rashin dawowar ciwo yayin maganin ƙwayoyi tare da gabapentin, akwai haɗarin sake dawowa da jijiyoyin ƙwayar tsoka a cikin marasa lafiya tare da nau'in nau'in motsa jiki na firgita. Yana da mahimmanci a tuna cewa miyagun ƙwayoyi ba kayan aiki masu tasiri ba ne a cikin yaƙi da cututtukan cututtukan ƙuraji.
Tare da haɗin gwiwa tare da Morphine, ana buƙatar ƙara yawan sashi na Gabagamma bayan tuntuɓar likita. A wannan yanayin, mai haƙuri yakamata ya kasance ƙarƙashin kulawa mai kulawa don likita don hana farkon bayyanar cututtuka na rashin kwanciyar hankali na tsarin juyayi na tsakiya (nutsuwa). Tare da ci gaban alamun rikice-rikice na tsarin juyayi, ya wajaba don rage yawan magungunan biyu.
Tare da haɗin gwiwa tare da Morphine, ana buƙatar ƙara yawan sashi na Gabagamma bayan tuntuɓar likita.
Yayin gudanar da nazarin dakin gwaje-gwaje, ana iya yin rikodin sakamako na gaskiya don kasancewar proteinuria, sabili da haka, lokacin zartar da Gabagamma tare da sauran magungunan anticonvulsants, ya zama dole a nemi ma'aikatan dakin gwaje-gwaje don gudanar da bincike a cikin takamaiman hanyar don haifar da sulfosalicylic acid.
Yi amfani da tsufa
Mutane sama da 60 da haihuwa basu da buƙatar daidaita sashi na ƙari.
Gudanar da Gabagamma ga Yara
Ba'a bada shawarar magungunan ga yara da matasa masu shekaru 18 da haihuwa ba, ban da wasu lokuta na rikice-rikice na ɓangarori.
Yi amfani da lokacin daukar ciki da lactation
Ba a gudanar da karatun asibiti game da tasirin magani a kan ci gaban tayi ba. Don haka, an shar'anta gabanpentin ga mata masu juna biyu ne kawai cikin matsanancin hali, lokacin da ingantaccen sakamako na miyagun ƙwayoyi ko haɗari ga rayuwar mahaifiyar ya fi girman haɗarin mahaifa.
An wajabta Gabapentin ga mata masu juna biyu kawai cikin matsanancin hali.
Abubuwan da ke aiki suna iya kasancewa a cikin madarar uwa, don haka ya kamata a bar shayar da mama nono yayin maganin ƙwayoyi.
Aikace-aikacen aiki mara kyau
A gaban kasala koda, gazaran tsari an daidaita shi gwargwadon sharewar halittarsa (Cl).
| Cl, ml / min | Sashi na yau da kullum ya kasu kashi uku |
| sama da 80 | 0.9-3.6 g |
| daga 50 zuwa 79 | 600-1800 mg |
| 30-49 | 0.3-0.9 g |
| daga 15 zuwa 29 | An tsara 300 MG tare da tazara ta awanni 24. |
| kasa da 15 |
Yawan damuwa
Tare da zagi da miyagun ƙwayoyi saboda kashi ɗaya na babban kashi, alamun ƙarin yawan ƙwayar cuta sun bayyana:
- Dizziness
- yanayin aiki na gani da fasalin abubuwa;
- matsalar magana;
- bari;
- nutsuwa
- zawo
Zai yiwu karuwa ko ƙarin haɗarin sauran halayen m. Dole ne a kwantar da wanda aka azabtar da shi don kamuwa da shi, idan dai an yi maganin kawunansu a baki 4 a cikin awa 4 da suka gabata. Kowace alamar rashin abin sama da ya kamata ana cire ta ta hanyar bayyanar cututtuka. Hemodialysis yana da tasiri.
Tare da yawan yawan shan magani, ƙwayar barci na iya faruwa.
Yin hulɗa tare da wasu kwayoyi
Tare da amfani da layi daya na amfani da Gabagamma tare da wasu kwayoyi, halayen masu zuwa suna faruwa:
- Idan kun dauki Morphine sa'o'i 2 kafin amfani da gabapentin, zaku iya ƙara yawan ƙarshen ƙarshen da 44%. A wannan yanayin, an lura da karuwa a matakin ƙusa zafi. Babu mahimmancin asibiti da aka kafa.
- A hade tare da antacids da shirye-shiryen da ke dauke da sinadarin magnesium da aluminium, an rage yawan bioavailability of gabapentin da kashi 20%. Don hana raunana tasirin warkewa, ana bada shawara don ɗaukar maganin kabagamma bayan sa'o'i 2 bayan shan maganin.
- Probenecid da cimetidine basa rage shakatawa da matakan serum na abu mai aiki.
- Phenytoin, hanawar hana baki, phenobarbital da carbamazepine ba su da tasiri a cikin ƙwayar plasma na gabapentin.
Amfani da barasa
A lokacin shan magani, haramun ne a sha giya. Ethanol a cikin abubuwan da ke tattare da giya yana da tasiri mai hana aiki a cikin tsarin jijiya na tsakiya kuma yana kara tasirin sakamako.
Analogs
Hanyoyin magungunan sun hada da:
- Katena
- Gabapentin;
- Neurontin;
- Tebantin;
- Kayan Convalis.
Canjawa zuwa wani magani ana yarda dashi bayan tattaunawar likita tare da ƙarancin ingancin Gabagamma ko tare da bayyanar da mummunan tasirin.
A matsayin analog, zaku iya amfani da Neurontin.
Yanayin hutu Gabagamma daga kantin magani
Ba'a sayar da maganin ba tare da takardar sayan likita ba.
Zan iya siye ba tare da takardar sayan magani ba
Sakamakon ƙara yawan haɗarin rashin damuwa na tsarin juyayi na tsakiya da kuma bayyanar da mummunan halayen daga wasu gabobin, sayayyar siyar da Gabagamma ta iyakance.
Farashin Gabagamma
Matsakaicin farashin maganin yana bambanta daga 400 zuwa 1150 rubles.
Yanayin ajiya na miyagun ƙwayoyi
An bada shawara don adana anticonvulsant a yanayin zafi har zuwa + 25 ° C a cikin wuri mai sanyi tare da ƙarancin zafi.
Ranar karewa
Shekaru 3
Gabagamma mai gabatarwa
Werwag Pharma GmbH & Co. KG, Jamus.
An bada shawara don adana anticonvulsant a yanayin zafi har zuwa + 25 ° C a wuri mai sanyi tare da ƙarancin zafi.
Reviews on Gabagamma
Izolda Veselova, dan shekara 39, St. Petersburg
An wajabta maganin capsules dangane da rassan neuralgia 2. Likita ya ce an saita sashi gwargwadon matsayin ingantaccen sakamako. A halin da nake ciki, Dole ne in dauki capsules 6 a kowace rana. Ya kamata a ɗauka cikin haɓaka mai ƙarfi: a farkon farawa, an fara shi da capsule 1-2 na kwanaki 7, bayan hakan ya ƙaru da kashi. Na yi la'akari da shi magani ne mai inganci na bugun jini. Ban lura da wani sakamako masu illa ba yayin jiyya. Wuraren ya tsaya.
Dominika Tikhonova, dan shekara 34, Rostov-on-Don
Ta ɗauki Gabagamma kamar yadda wata ƙwararren masanin kimiyyar ƙwaƙwalwar ƙwaƙwalwa ta tsara shi dangane da trigeminal neuropathy. Carbamazepine bai dace da halin da nake ciki ba. Capsules ya taimaka tare da dabaru na farko. Hanyar magani na kwayar cutar ta kasance tsawon watanni 3 daga Mayu 2015. Duk da cutar sankarar cuta, zafin da alamomin cututtukan cuta sun shude.Iyakar abin da ya jawo shine farashin. Don capsule 25 dole ne in biya ruhu 1200.
