Tasirin Tritace Plus yana dogara da tasirin ramipril da hydrochlorothiazide. Duk abubuwan haɗin biyu suna hana canji na angiotensin I cikin nau'in angiotensin II, don haka cimma sakamako na antihypertensive. A wannan yanayin, ba da wuya a sanya maganin a cikin aikin asibiti kamar monotherapy. Marasa lafiya suna karɓar wakili mai narkewa a matsayin wani ɓangare na hadaddun jiyya na hauhawar jijiya don cimma matakan tsayayyen jini.
Sunan kasa da kasa mai zaman kansa
Hydrochlorothiazide + Ramipril.
ATX
C09BA05.
Tasirin Tritace Plus yana dogara da tasirin ramipril da hydrochlorothiazide.
Saki siffofin da abun da ke ciki
Akwai magungunan a cikin kwamfutar hannu. 1 kwamfutar hannu hada da 2 mahadi aiki - ramipril da hydrochlorothiazide.
| Abubuwan haɗin aiki | Haduwa mai yuwuwar, mg | |||
| Ramipril | 12,5 | 12,5 | 25 | 25 |
| Hydrochlorothiazide | 5 | 10 | 5 | 10 |
| Kwayoyin masu launi | ruwan hoda | lemu mai zaki | fari | ruwan hoda |
Don haɓaka ma'auni na pharmacokinetic, ana amfani da ƙarin kayan maye:
- sodium stearyl fumarate;
- baƙin ƙarfe baƙin ƙarfe, wanda ke ba Allunan launi mai launi iri ɗaya dangane da haɗakar abubuwan da aka haɗa;
- gelatinized masara sitaci;
- microcrystalline cellulose;
- maganin.
Allunan, tare da layin rarraba.
Ba safai ba ne aka bayar da magani ga aikin asibiti kamar yadda ake kula da shi.
Aikin magunguna
Tritace ya haɗu da maganin hana ƙwaƙwalwar angiotensin wanda ke canza enzyme (ACE) inhibitor - ramipril, da thiazide diuretic hydrochlorothiazide. Haɗin abubuwa masu aiki suna da tasiri mai ƙarfi na antihypertensive. Abun hanawa na ACE yana hana samuwar angiotensin II, wanda ya zama dole don rage ƙyalli na jijiyoyin bugun zuciya.
Ramipril yana hana faruwar sakamako na vasoconstrictor kuma yana hana fashewar bradykinin, abu ne don haɓaka yanayin jini na jijiyoyin jini. Hydrochlorothiazide yana haɓaka vasodilation, saboda wanda tasoshin ke ƙaruwa da ƙari. Yana da mahimmanci a kula da ƙimar jini don hana haɓakar bradycardia da jijiyoyin jini.
Ana lura da mafi girman tasirin warkewa 3-6 hours bayan aikace-aikace kuma yaci gaba har kwana guda. Sakamakon diuretic na thiazide diuretic na tsawon awa 6-12.
Pharmacokinetics
Ramipril da hydrochlorothiazide suna haɗuwa da hanzari a cikin jejunum na kusanci, daga inda suke yaduwa cikin tsarin kewaya. A bioavailability na hydrochlorothiazide ne 70%. A cikin jini, duka mahaɗin sunadarai sun isa mafi yawan maida hankali a cikin sa'o'i 2-4. Ramipril yana da babban matsayi na ɗaurin garkuwar plasma - 73%, yayin da 40% na hydrochlorothiazide ne ke samar da hadaddun tare da albumin.
Rabin rayuwar bangarorin biyu yakai awowi 5-6. Ramipril shine kashi 60% cikin haɗin tare da fitsari. Hydrochlorothiazide yana barin jikin a ainihinsa ta hanyar 95% ta hanjin kodan a cikin awanni 24.
Alamu don amfani
Ana buƙatar magani don rage hawan jini.
Ana buƙatar magani don rage hawan jini.
Contraindications
Magungunan yana contraindicated a cikin mutane da:
- hypersensitivity to hydrochlorothiazide, ramipril da sauran abubuwa na Tritace;
- tsinkayar ci gaban Quincke edema;
- mai saurin lalata na koda;
- canje-canje a cikin ƙwayoyin plasma electrolytes: potassium, magnesium, alli;
- mummunan cutar hanta;
- mai tsanani jijiya jini.
Tare da kulawa
Wajibi ne a kula da jin daɗi gaba ɗaya a lokacin da ake amfani da maganin ƙwaƙwalwa a gaban abubuwan da ke biyo baya:
- tsananin rauni na zuciya;
- rikice-rikice a cikin ventricle na hagu, wanda halayyar canje-canje na hauhawar jini;
- stenosis na babban, tasoshin cerebral, na jijiyoyin jini ko jijiya;
- tashin hankali na ruwa-electrolyte metabolism;
- tare da keɓantaccen creatinine na 30-60 ml / min;
- lokacin farfadowa bayan sakewar koda;
- cutar hanta
- lalacewar nama mai haɗuwa - scleroderma, lupus erythematosus;
- zalunci na bazarar jini
Marasa lafiya waɗanda a da suka ɗauki diuretics suna buƙatar sarrafa yanayin ma'aunin ruwan-gishiri.
Yadda ake ɗaukar Tritace Plus
Ba a sanya magani ba azaman maganin farko mai amfani da ƙwayoyin cuta. Allunan an yi niyya don amfani da baka. Shan magani da safe ana bada shawara. An ƙaddara sashi ne ta ƙwararren likita dangane da alamu na hawan jini (BP) da tsananin hauhawar jini.
Matsakaicin ma'auni a farkon maganin ƙwayar cuta shine 2.5 mg na ramipril a hade tare da 12.5 MG na hydrochlorothiazide. Tare da haƙuri mai kyau, don haɓaka sakamako mai banƙyama, za a iya ƙara yawan sashi bayan makonni 2-3.
Tare da ciwon sukari
Magungunan zai iya haifar da hypoglycemia tare da amfani da jituwa ta hanyar amfani da magungunan hypoglycemic ko insulin, sabili da haka, yayin kulawa tare da magungunan antihypertensive, ya zama dole don daidaita sashi na maganin antidiabetic. Marasa lafiya da ciwon sukari suna buƙatar kulawa da matakan glucose na jini koyaushe.
Sakamakon sakamako na Tritace Plus
A mafi yawan lokuta, rashin isowar Tritace yana haifar da gajiya da zazzabi.
Gastrointestinal fili
Rashin narkewar ƙwayar cuta ana ma'anar ci gaban kumburi da mucous membranes, bayyanar gingivitis, amaiji na maye, da maƙarƙashiya. Wataƙila ci gaban gastritis, rashin jin daɗi a cikin ciki.
Tare da cututtukan gastrointestinal, gastritis na iya haɓaka azaman sakamako mai illa.
Hematopoietic gabobin
Tare da raguwa a cikin ƙwayoyin jini na jini, yawan ƙwayoyin jini mai siffa yana raguwa.
Tsarin juyayi na tsakiya
Tare da asarar sarrafa hankali-tunanin mutum, mai haƙuri yana da bacin rai, damuwa, da rashin bacci. A kan tushen yanayin juyayi na tsarin juyayi, akwai asarar daidaituwa a sararin samaniya, ciwon kai, ƙonawa mai ƙonawa, asara ko dandano mai tayar da hankali.
Daga tsarin urinary
Wataƙila karuwa da yawan fitsari da aka saki da haɓakar ƙoshin koda.
Daga tsarin numfashi
A mafi yawan lokuta, saboda karuwa a cikin matakin bradykinin, busassun tari na iya haɓaka, a wasu marasa lafiya - ambaliyar hanci da kumburi da sinuses.
A ɓangaren fata
Akwai haɗarin haɓakar angioedema, wanda zai haifar da asphyxia a wasu yanayi. Psoriasis-kamar bayyanar cututtuka, ƙara yawan shaye, rashes, itching da erythema na daban-daban etiologies suna yiwuwa.
Sakamakon shan maganin, erythema na etiologies daban-daban na iya haɓaka.
Daga tsarin kare jini
A cikin maza, raguwa cikin tashin hankali da haɓaka a cikin ƙwayoyin mammary suna yiwuwa.
Daga tsarin zuciya
Wataƙila raguwar hauhawar jini, hauhawar jini saboda rashin ruwa, ƙonewar manyan tasoshin, hanawa zagayawa jini, kumburi bango na jijiyoyin jiki da cutar Raynaud.
Tsarin Endocrin
Zai iya yiwuwa ne a kara samar da sinadarai na antidiuretic.
A wani ɓangaren hanta da ƙwayar biliary
A cikin lokuta na musamman, kumburin cytolytic na hanta yana haɓaka tare da yiwuwar sakamako mai mutuwa. Akwai karuwa a matakin bilirubin a cikin jini da faruwar cutar cholecystitis na lissafi.
Cutar Al'aura
Ana haifar da rikicewar cututtukan ƙwayar cuta ta hanyar bayyanar halayen fata.
Ana haifar da rikicewar cututtukan ƙwayar cuta ta hanyar bayyanar halayen fata.
Daga cikin tsarin musculoskeletal da nama mai hadewa
Mutum na iya jin zafi da rauni a cikin tsokoki.
Daga gefen metabolism
A cikin lokuta na musamman, akwai raguwa ga haƙurin nama zuwa glucose, saboda abin da sukari jini ke ƙaruwa. A take hakkin metabolism na gaba daya, sinadarin urea a cikin jini yana karuwa, gout yana kara dagula cutar anorexia. A cikin mafi yawan lokuta, hypokalemia da acidosis metabolic na haɓaka.
Daga tsarin rigakafi
Wataƙila haɓakar halayen anaphylactic dangane da haɓaka ƙarar rigakafi na rigakafi. Tritace Yanayin aiki na iya tayar da jiji da kai na fuska, karamin hanji, wata gabar jiki da kuma harshe.
Tasiri kan ikon sarrafa abubuwan inji
Sakamakon yiwuwar raguwar gani da asarar hankali, mai haƙuri dole ne yayi hankali lokacin tuki na'urori masu rikitarwa ko abubuwan hawa waɗanda ke buƙatar babban saurin halayen psychomotor da haɓaka taro.
Sakamakon raguwar yiwuwar gani da asarar hankali, mai haƙuri yana buƙatar yin hankali lokacin tuki na'urori masu fashewa ko abubuwan hawa.
Umarni na musamman
Kafin aikin tiyata na tiyata, ya zama dole a gargaɗi likitan tiyata da likitan da ke cikin aikin game da jiyya tare da mai hana ACE. Wannan ya zama dole don hana raguwar hauhawar jini yayin aikin.
Yi amfani da lokacin daukar ciki da lactation
Sakamakon yiwuwar cutar teratogenic da fetotoxic, ba a ba da magunguna ga mata masu juna biyu. Akwai hadarin kamuwa da cutar mahaifa a cikin tayin.
Yayin jiyya, dole ne a daina shayar da nono.
Alƙawarin Tritace Plus na yara
Sakamakon karancin bayanai kan tasirin Tritace akan jikin dan adam yayin ci gaban, an sanya kwayar cutar a cikin yara ‘yan kasa da shekaru 18.
Yi amfani da tsufa
Tsofaffi mutane ba sa bukatar yin canje-canje ga tsarin ilimin.
Tsofaffi mutane ba sa bukatar yin canje-canje ga tsarin ilimin.
Aikace-aikacen aiki mara kyau
Marasa lafiya da ke fama da cutar koda da matsakaiciyar ƙwayar cuta ya kamata su saka idanu kan ayyukan ayyukan gabobin yayin aikin jiyya.
Amfani don aikin hanta mai rauni
An haramta amfani da miyagun ƙwayoyi don amfani da mutanen da ke da lalata hanta.
Yawan adadin ƙwayoyin Tritace Plus
Hoto na asibiti na yawan abin sama da ya wuce yana bayyana kanta a cikin cin zarafin wakili kuma yana bayyanar da alamun bayyanar cututtuka masu zuwa:
- polyuria, wanda a cikin marasa lafiya tare da benign prostatic adenoma ko wasu raunin fitar fitsari ya haifar da ci gaba na tururi na urination tare da nisantar mafitsara;
- bradycardia, arrhythmia;
- na kusa da jijiyoyin jiki;
- take hakkin metabolism na ruwa-electrolyte;
- rikicewa da rashi na hankali tare da haɓaka mai biyo baya;
- ƙwayar tsoka;
- hanji mai santsi mara nauyi.
Idan kasa da mintuna 30 zuwa 90 kenan tun lokacin da aka dauki kwayar, to ya wajaba ga wanda aka azabtar ya jawo amai da kuma matse ciki. Bayan hanyar, mai haƙuri ya kamata ya ɗauki adsorbent don rage jinkirin shan abubuwa masu aiki. Tare da bradycardia mai tsanani, ya zama dole a gabatar da 1-2 mg na adrenaline ko kuma kafa na'urar bugun zuciya na ɗan lokaci. Game da yawan abin sama da ya kamata, ya zama dole don kula da matakin halittar kwayar halittar jini da karfin jini yayin jiyya.
Tare da yawan shaye-shaye na miyagun ƙwayoyi, ƙwayar tsoka na iya bayyana.
Yin hulɗa tare da wasu kwayoyi
Tare da gudanarwa na lokaci guda na Tritace tare da thiazides, yawan ƙwayoyin cholesterol a cikin ƙwayar jini na iya ƙaruwa.
Abubuwan haɗin gwiwa
An lura da rashin daidaituwa na magunguna tare da amfani da layi daya na aliskiren da antagonensin II antagonists. A cikin maganar ta ƙarshe, an ba da izinin kulawa a cikin marasa lafiya tare da ciwon sukari na polyneuropathy. Ba a ba da umarnin Aliskiren don matsakaici zuwa ga lalacewa ta koda ba.
Ba da shawarar haɗuwa ba
Ba za a iya haɗawa da wakilin antihypertensive tare da kwayoyin hana barci ba, salts lithium, tacrolimus tare da sulfamethoxazole.
Haɗuwa yana buƙatar taka tsantsan
Wajibi ne a kiyaye matakan tsaro a alƙawarin layi daya:
- tricyclic antidepressants;
- sauran magungunan antihypertensive;
- Kalaman acid na ruwa;
- kudi don maganin sa barci;
- maganin sodium chloride;
- magungunan diuretic;
- vasopressor jin tausayi;
- allopurinol, jami'in immunomodulatory, glucocorticosteroids, cytostatics;
- estramustine, heparin, vildagliptin;
- maharan hypoglycemic.
A lokacin jiyya, bai kamata a yi amfani da shirye-shiryen da ke kunshe-kayan abinci da kayan maye ba.
Wajibi ne a dakatar da shan ethanol.
Amfani da barasa
A lokacin jiyya, bai kamata a yi amfani da shirye-shiryen da ke kunshe-kayan abinci da kayan maye ba. Lokacin ɗaukar Tritace tare da ethanol a layi daya, akwai haɗarin rushewa.
Analogs
Canjin zuwa wani magani mai kare kansa yana gudana ne a karkashin kulawar likita, wanda zai iya ɗauka ɗayan magunguna masu zuwa azaman maganin maye:
- Hartil-D;
- Amprilan NL;
- Amprilan ND;
- Wazolong H;
- Ramazid H.
Analogs sun sami dama a cikin kewayon farashin - 210-358 rubles.
Magunguna kan bar sharuɗan
An saya don dalilai na likita.
Zan iya siye ba tare da takardar sayan magani ba
Magungunan zai iya haifar da maganin orthostatic idan an yi amfani dashi ba tare da dacewa ba. Don amincin marasa lafiya a cikin kantin magani, ana iya sayan magani kawai tare da takardar sayen magani.
Farashi akan Tritac Plus
Matsakaicin farashin 5 Allunan kwayoyi shine 954-1212 rubles, tare da sashi na 10 MG - 1537 rubles.
Yanayin ajiya na miyagun ƙwayoyi
Allunan za a adana su a zazzabi na + 8 ... + 30 ° C a wani wuri da aka keɓe daga aikin hasken rana.
Ranar karewa
Shekaru 3
Mai masana'anta
Sanofi Aventis, Italiya.
Neman Tritac Plus
Binciken da ya dace game da miyagun ƙwayoyi ya nuna cewa miyagun ƙwayoyi sun kafa kanta a cikin kasuwar magunguna.
Likitoci
Svetlana Gorbacheva, likitan zuciya, Ryazan
Wakili mai amfani da hydrochlorothiazide. Sinadaran yana haɓaka tasirin antihypertensive. Ina sanya magani ga marasa lafiya na kawai tare da hauhawar jini na tsoka guda ɗaya kowace rana. Tsawan lokacin jiyya shine mutum ɗaya ga kowane mai haƙuri. Ba a lura da wata illa ba. Ba a yarda mutanen da ke fama da rauni na koda sun sha maganin.
Marasa lafiya
Alexey Lebedev, dan shekara 30, Yaroslavl
Mahaifiyar ta fara bayyana hauhawar jini tare da tsufa. Saboda hauhawar jini, yakamata a sha magunguna na yau da kullun. A cikin 'yan kwanakin da suka gabata, Tritace ta kasance mai taimako na dogon lokaci. Allunan suna daidaita hawan jini sosai kuma basa haifar da sakamako masu illa. Tare da amfani da tsawan lokaci, kuna buƙatar ɗaukar hutu ko ƙara yawan sashi, saboda jiki ya daina fahimtar tasirin allunan. Iyakar abin da aka jawo shi ne ɗanɗano mai ɗaci.
Elena Shashkina, shekara 42, Vladivostok
An fitar da Tritace ga mahaifiyarta bayan bugun jini sakamakon hauhawar jini. Magungunan sun taimaka - inna ta ji daɗi, sauye sauye mai ƙarfi ya tsaya. Mama tana ɗaukar ƙaramin ƙima don maganin ya daɗe. Dangane da shawarar likitan, bayan wata daya na shigar da kullun, ta daina amfani da ita don makonni 1-2. Wannan ya zama dole saboda babu wasu illa da jaraba.
