Captopril-FPO magani ne mai ƙoshin ƙwaƙwalwa saboda tasirin vasodilating. Sakamakon warkewa shine saboda hanawar ACE da hanawar kai tsaye na rushewar bradykinin. Magungunan yana hana samuwar angiotensin 2. Sakamakon yaduwar tasoshin jijiyoyi da na waje, haɓaka kewaya jini a cikin yankin ischemia, yanayin mai haƙuri yana inganta a kan tushen abubuwan da ke tattare da tsarin jijiyoyin zuciya na asali daban-daban. Dole ne a sha miyagun ƙwayoyi daidai da umarnin likitan masu halartar.
Sunan kasa da kasa mai zaman kansa
Kyaftin
Captopril-FPO magani ne mai ƙoshin ƙwaƙwalwa saboda tasirin vasodilating.
ATX
C09AA01.
Saki siffofin da abun da ke ciki
Ana samun magungunan a cikin nau'i na farin allunan tare da tint mai tsami, dauke da 25 ko 50 MG na kayan aiki - captopril. Don haɓaka sha da bioavailability yayin ƙirar masana'antu, ana ƙara mahadi mai taimako zuwa ɓangaren aiki mai aiki:
- microcrystalline cellulose;
- sitaci masara;
- sukari madara;
- magnesium stearate;
- aerosil.
Unitsungiyoyin magani na iya samun warin halayyar. Allunan suna cikin kunshin a blister fakiti na 5-10 guda.
Aikin magunguna
Magungunan yana cikin rukunan magungunan antihypertensive, tsarin da aka samo shi ya danganta da shinge na angiotensin wanda ke canza enzyme (ACE). A sakamakon sakamako na warkewa, canzawar angiotensin I zuwa Tsarin Na II yayi jinkirin, wanda yake haifar da vasoconstriction - spasm na endothelium na jijiyoyin jiki. Tare da takaitaccen ƙwayar bututun jirgin ruwa a gaba da ƙayyadaddun ƙarfin ƙwayar jini, hawan jini ya tashi. Magungunan yana hana spasm, don haka dakatar da rushewar bradykinin, enzyme wanda ke yanke tasirin jini.
Captopril FPO yana rage jinkirin ci gaban faduwar zuciya.
A sakamakon haka, tasoshin suna faɗaɗawa kuma matsin lamba ya ragu zuwa al'ada, muddin dai yawan ƙarfin jinin ya isa ya cika gadoji. ACE inhibitor saboda matsin lamba yana da matakan da suka biyo baya:
- rage juriya a cikin jijiyoyin huhun da na gefe;
- yana ƙaruwa da juriya ga jijiyoyi, yana rage haɗarin rubewar bango na gudanawar jini;
- yana hana keta aikin ventricle na hagu, sakamakon hawan jini (BP);
- yana rage jinkirin ci gaban zuciya;
- yana rage yawan haɗuwar sodium a cikin jini na plasma a ƙasan asali daga mummunan yanayin bugun zuciya;
- inganta aikin jijiya da jijiyoyin zuciya da kuma microcirculation a cikin yankunan ischemic.
Maganin yana hana adon jikin platelet.
Pharmacokinetics
Bayan gudanar da baki, allon rubutu ya ninka kashi 75% cikin bangon jejunum. Tare da abinci mai layi ɗaya, ana rage sha daga kashi 35-40. Bangaren mai aiki ya kai mafi girman dabi'u a cikin jiki a cikin mintuna 30 zuwa 90. Matsakaicin ɗauri zuwa ga albumin plasma lokacin da ya shiga cikin jijiyar jini yana da ƙasa - 25-30%. A cikin nau'ikan irin wannan hadaddun, ana amfani da maganin a cikin hepatocytes tare da ƙirƙirar samfuran samfuran biotransformation waɗanda basu da tasirin magani.
Fiye da 95% na captopril suna barin jiki tare da taimakon kodan, tare da an raba kashi 50% a asalinsa.
Rabin-rabi kasa da sa'o'i 3. Lokaci yana ƙaruwa game da tushen ci baya na koda daga 1-29 hours, gwargwadon tsananin cutar. Fiye da 95% na captopril suna barin jiki tare da taimakon kodan, tare da an raba kashi 50% a asalinsa.
Abinda ya taimaka
Ana amfani da maganin a cikin aikin likita don magani da rigakafin waɗannan hanyoyin cututtukan:
- hawan jini, gami da farfadowa;
- a matsayin wani bangare na cikakken magani don kawar da raunin zuciya;
- rikicewar aiki na aikin ventricle hagu bayan bugun zuciya, idan har mai haƙuri ya tabbata;
- lalacewar kayan aikin na cikin ƙasa da na paalyma na ƙasa a cikin nau'in 1 na ciwon sukari.
Contraindications
An haramta amfani da miyagun ƙwayoyi don amfani da mutanen da ke da haɗin kai ga mutum da kuma sauran abubuwan da ke yin maganin. Saboda kasancewar lactose monohydrate, ba a bada shawarar yin amfani da Captopril don amfani da shi ga mutanen da ke fama da malalatawa na monosaccharides, rashin haƙuri ko rashi lactase.
Sashi
An kafa sashi ne ta kowane kwararre ta hanyar likitancin zuciya, wanda ya dogara da alamomin dakin gwaje-gwaje da kuma tsananin cutar. Magungunan an yi niyya ne ga marasa lafiyar da shekarunsu suka wuce 18. Shawarar farawa shine 12.5 mg 2 sau a rana.
Tare da ciwon sukari nephropathy
Don rigakafi da magani na nephropathy a kan asalin ciwon sukari na dogaro da insulin, ya zama dole a sha daga kashi 75 zuwa 100 na maganin a rana.
A cikin raunin zuciya
Rashin bugun zuciya yana buƙatar yin amfani da 25 MG sau 3 a rana a matakin farko na magani. Tare da hauhawar jini na yau da kullun ko maras kyau, kazalika da marasa lafiya da hypovolemia da ƙananan sodium a cikin jini, ana bada shawara don rage sashi zuwa 6.25-12.5 mg tare da mitar gudanarwa har zuwa sau 3 a rana. A matsayin maganin kiyayewa, sau 3 a rana ya kamata a sha 12.5 ko 25 MG, ya danganta da matakin haƙuri ga miyagun ƙwayoyi.
A karkashin matsin lamba
Don kwantar da hawan jini na tsananin rauni ko matsakaici a farkon jiyya, yakamata a dauki 25 MG sau 2 a rana. Tare da ƙarancin warkewar magani, ya kamata a ƙara yawan sashi zuwa 50 MG kawai idan an yi haƙuri da shi sosai. Matsakaicin da aka yarda da shi a rana shine 150 MG.
Idan ba a sami alamun da ake buƙata ba na bugun jini a cikin kwanakin 14-21 na maganin, ana kara thiazide diuretics zuwa maganin monotherapy na captopril-FPO. Ana lura da halayen jiki na makonni 1-2. Don kawar da mummunan yanayin aikin cuta, zaku iya ƙara yawan guda ɗaya zuwa 100-150 MG tare da mitar gudanarwa har zuwa sau 2-3 a rana.
Don kawar da matsalar hauhawar jini, ya zama dole a sanya maganin a ƙarƙashin harshen tare da sashi na 6.25-50 MG.
Don kawar da matsalar hauhawar jini, ya zama dole a sanya maganin a ƙarƙashin harshen tare da sashi na 6.25-50 MG. Ana lura da maganin warkewa bayan mintuna 15-30.
Tare da infarction myocardial
An wajabta magungunan har tsawon kwanaki 3 bayan infarction na haila. Adadin a farkon maganin magani shine 6.25 MG kowace rana. Tare da kyakkyawar amsawar jiki ga miyagun ƙwayoyi, haɓaka ƙimar yau da kullun zuwa 12.5 MG tare da mitar gudanarwa har zuwa sau 3 a rana. A cikin 'yan makonni, an kara sashi zuwa mafi girman jurewa.
Yadda ake ɗaukar Captopril-FPO
Allunan ana shansu a kan komai a ciki na mintina 60 kafin cin abinci, saboda abinci yana raguwa ko kuma ya hana ma'amala da maganin.
A karkashin harshe ko sha
Ana amfani da subtopual captopril kawai don hanzarta sakamako mai warkewa. Rage hawan jini a cikin gaggawa ya zama tilas idan aka sami wani tashin hankali.
Har yaushe ze dauka?
Tare da sublingual management, da hypotensive sakamako ana lura da mintuna 15-30 bayan an warwatse kwamfutar hannu a karkashin harshe. Lokacin da aka shiga ciki, ana samun tasirin warkewa a cikin sa'o'i 3-6, farkon - bayan sa'o'i 1-2.
Sau nawa zan iya sha
Yawan aiki da yawa - sau 2-3 a rana.
Side effects
Sakamakon mara kyau yana haɓaka sakamakon tsari na rashin daidaituwa. Lokacin da suka bayyana, ana bada shawarar rage ƙarfin kashi.
Gastrointestinal fili
Sakamakon sakamako a cikin narkewa kamar jijiyoyi:
- tashin zuciya
- rage cin abinci;
- ku ɗanɗani rikici;
- zafin ciki;
- haɓaka aikin enzymatic na hepatic transaminases;
- hyperbilirubinemia;
- zawo, maƙarƙashiya;
- ci gaban mai mai narkewa na hanta.
A cikin lokuta masu saukin ganewa, ragi na bile yana yiwuwa. An sami keɓancewa da keɓancewa da kumburin ƙwayar huhu.
Hematopoietic gabobin
Ba a daɗe ana ɗaukar rikice rikicewar ƙwaƙwalwar kashi:
- anemia
- raguwa a cikin adadin ƙwayoyin jini;
- raguwa akan samuwar platelet.
A cikin marasa lafiya da cututtukan autoimmune, agranulocytosis na iya faruwa.
Tsarin juyayi na tsakiya
Tare da lalacewar tsarin juyayi, akwai haɗarin rashin jin tsoro, ciwon kai, gajiya mai rauni, paresthesias. Lalacewa zai iya zama mai illa.
Daga tsarin urinary
A wasu halaye, ana iya fitar da furotin a cikin fitsari, abubuwan da ke cikin uric acid da creatinine a cikin jini yana tashi, acidosis yana haɓaka.
Daga tsarin numfashi
Bayyanar bushewar mai yiwuwa.
A ɓangaren fata
Abubuwan da suka shafi fatar jiki suna bayyana azaman maculopapular fatar jiki ko itching. A cikin marasa lafiya da aka ƙaddara ga haɓakar rashin lafiyar, rashin lafiyar Stevens-Johnson, ciwon urticaria, ko tuntuɓar dermatitis na iya bayyana.
Daga tsarin kare jini
A cikin maza, yana faɗaɗa girman nono ko haɓakar rashin ƙarfi erectile yana yiwuwa.
Cutar Al'aura
Allergy yana bayyana a cikin nau'i na halayen fata, bronchospasm tare da toshewar hanji, ƙurawar Quincke, girgiza ƙwayar cuta, tashin zuciya, da kasancewar ƙwayoyin rigakafi a cikin jini.
Tasiri kan ikon sarrafa abubuwan inji
Magungunan ba ya shafar aikin ƙwarewar motsa jiki, tunanin mutum da yanayin lafiyar mai haƙuri. Sabili da haka, a lokacin da ake tare da Captopril, babu buƙatar iyakance lokacin tuki mota ko aiki tare da keɓaɓɓun hanyoyin.
Umarni na musamman
An yi taka tsantsan yayin ɗaukar waɗannan sharuɗɗan:
- stenosis na arteries na kodan;
- cututtukan zuciya;
- haɗarin mahaifa;
- bayyana cututtukan autoimmune;
- zalunci da samuwar jini;
- ciwon sukari mellitus;
- lokacin farfadowa bayan sakewar koda;
- aortic stenosis;
- karancin abincin sodium
- tsufa;
- karancin jini yana yaduwar jini, rashin ruwa.
Yayin maganin ƙwayar cuta, ya zama dole a faɗakar da ma'aikatan dakin gwaje-gwaje game da yiwuwar faruwar sakamako na ƙarya yayin nazarin fitsari don kasancewar acetone.
Yi amfani da lokacin daukar ciki da lactation
Yin amfani da miyagun ƙwayoyi a cikin satin na II da na III na ci gaban tayi yana nuna fetotoxicity, saboda wanda saitin gabobin a tayin na iya tayar da hankali. Yiwuwar haihuwar tayi girma. An haramta wa mata masu juna biyu amfani da maganin.
An kebe Captopril tare da madara mai nono, sabili da haka, yayin shayarwa, ya wajaba a dakatar da lactation.
Amfani da barasa
An haramta yin amfani da miyagun ƙwayoyi don amfani dashi tare da giya, sabili da haka, a yayin da ake amfani da maganin miyagun ƙwayoyi, bai kamata ku sha giya ba ko ɗaukar samfuran ethanol. Ethyl barasa yana rage tasirin antihypertensive, yana kara haɗarin haɗarin jini a sakamakon haɗuwar platelet kuma yana ƙaruwa da rashin lalacewa.
Yawan damuwa
Game da yawan shaye-shaye na miyagun ƙwayoyi, raguwar haɓakar hawan jini zai yiwu. Sakamakon tashin hankali na jijiyoyin jiki, mutum na iya rasa hankali, ya fadi cikin rashin lafiya ko coma, kuma kamewar zuciya yana yiwuwa. Tare da cutar da ƙwayar cuta mai sauƙi, shugaban yana fara zubewa, zazzabi a cikin ƙafafunsa yana raguwa.
Don daidaita ƙwanƙwasawar jini, wajibi ne don tilasta wanda aka azabtar ya kwanta a bayansa kuma ya ɗaga kafafunsa. A cikin tsaran yanayi, ana wajabta magani kamar yadda ya kamata.
Yin hulɗa tare da wasu kwayoyi
Amfani da keɓaɓɓen amfani da maganin ƙwayoyin cuta tare da wasu kwayoyi yana nunawa ga halayen masu zuwa:
- Magungunan cytostatic da rigakafi, azathioprine suna kara saurin kamuwa da cutar leukopenia. Azathioprine yana tsokane raguwa a cikin kashin baya jini.
- Magungunan da ke dauke da sinadarai a cikin jiki da kuma magungunan anti-steroidal anti-inflammatory na iya haifar da cututtukan hyperkalemia. AC inhibitor yana rage yawan aldosterone, saboda wanda akwai jinkiri a cikin ions na potassium.
- Tare da amfani da lokaci daya tare da magungunan diuretic, ana lura da sakamako mai ƙarfi. Sakamakon haka, haɓakar mummunan yanayin jijiyoyin jini, hyperkalemia, da lalata koda yana yiwuwa. Hakanan, ana lura da raguwar hauhawar jini tare da gabatar da kudade don maganin sa barci na gaba ɗaya.
- Allopurinol yana kara yiwuwar haɓakar halayen rashin lafiyan cuta da cututtukan zuciya.
- Acetylsalicylic acid, ibuprofen da indomethacin suna rage tasirin warkewa na maganin kwakwalwa.
- Captopril yana haɓaka ƙwayar ƙwayar plaoma na digoxin.
Magungunan rigakafin ƙwayoyin cuta na Cyclosporin na iya haifar da ci gaban oliguria da raunana aikin kodan.
Analogs
Allunan Captopril-FPO in babu mahimmancin tasirin antihypertensive ana iya maye gurbinsu da magunguna masu zuwa:
- Kapoten;
- Blockordil;
- Captopril Sandoz;
- Angiopril;
- Rilcapton;
- Captopril-STI;
- Kabas-Akos.
Ta yaya captopril-FPO ya bambanta da captopril
Generic, ba kamar maganin na asali ba, yana da tsawon rai yana da tasiri kuma yana da haɓaka tasirin warkewa.
Yanayin hutu don captopril-FPO daga kantin magani
An ba da izinin sayan don dalilai na likita kai tsaye.
Zan iya siye ba tare da takardar sayan magani ba
Sakamakon amfani da shi ba daidai ba, haɓakar ƙwayar jijiya mai yiwuwa ne, saboda haka haramun ne sayan Captopril ba tare da takardar izinin likita ba.
Farashin kuɗi don captopril-FPO
Matsakaicin matsakaici a cikin kantin magani shine 128 rubles.
Yanayin ajiya na miyagun ƙwayoyi
An ba da shawarar kiyaye miyagun ƙwayoyi a wani wuri da keɓe daga hasken rana, a zazzabi da ba ya wuce + 25 ° C
Ranar karewa
Shekaru 3
Kayayyakin Kamfanin Kaftin-Kaftin-FPO
CJSC FP Obolenskoye, Rasha.
Nazarin likitoci da marasa lafiya game da Captopril-FPO
Olga Kabanova, likitan zuciya, Moscow
Na lura cewa Captopril da kayanta ba sa aiki a kan duk masu haƙuri. Zan iya ba da shawarar magani don rage karfin jini a cikin yanayin gaggawa. Kuna iya shan maganin har sau 3 a rana. A wasu halaye, marasa lafiya suna koka da tsananin tari. Yi amfani da hankali idan akwai sakacin koda.
Ulyana Solovyova, mai shekara 39, Vladivostok
Na bar kyakkyawan nazari. Easilyan ƙaramin kwamfutar hannu fari an raba shi zuwa sassa 4 godiya ga notches na musamman. A halin da nake ciki, likita ya ba da shawarar sanya maganin a ƙarƙashin harshen don aiwatar da sauri. An wajabta don rage gaggawa a cikin hauhawar jini. An lura da matakin na tsawon mintuna 5. Ban sami fursunoni ba, sai don ɗanɗano mai ɗaci. Ba ni da niyyar maye gurbin maganin. Babu sakamako masu illa.
