Galvus Met shine sabon tushen maganin cututtukan sukari, abubuwan da ke aiki a ciki sune vildagliptin da metformin. Magungunan za su iya inganta glycemia sosai: a cikin rukunin sarrafawa na shekara don gudanarwa, ya taimaka wajen rage glycated haemoglobin da 1.5%. Shan waɗannan kwayoyin yana sa cutar sukari ta mellitus mafi aminci ta rage adadin hypoglycemia ta 5.5 sau. Kashi 95% na marasa lafiya marasa lafiya sun gamsu da wannan magani kuma suna shirin yin hakan gaba.
Galvus wani nau'in magani ne, ya ƙunshi kawai vildagliptin. Allunan za a iya haɗe su da metformin, abubuwan da keɓaɓɓe na sulfonylurea, maganin insulin.
Umarnin don amfani
Aikin Galvus ya samo asali ne sakamakon cutarwar da ake samu. Wadannan sune kwayoyin halittun da ke hade cikin jiki bayan sun ci abinci. Suna daskarar da ɓoyewa da sakin insulin. Vildagliptin a cikin abun da ke ciki na Galvus yana tsawaita aikin ɗayan ɗayan abubuwa - glucagon-like peptide-1. Dangane da aji na maganin, kayan suna cikin masu hanawar DPP-4.
Kamfanin Switzerland din Novartis Pharma ne ya samar da maganin, gaba daya aikin yana cikin Turai. Anyi rajista na Vildagliptin a cikin rajistar magungunan Rasha ba da daɗewa ba, a 2008. A cikin shekaru goma da suka gabata, ƙwarewar nasara don amfani da miyagun ƙwayoyi ya tara, an haɗa shi cikin jerin masu mahimmanci.
A tunani, yanzu duk wani mai ciwon sukari da ke dauke da cutar 2 zai iya samun shi kyauta. A aikace, irin waɗannan alƙawura ba kasafai ba ne, tunda magani yana da tsada sosai. Matsakaicin maganin Galvus na shekara-shekara shine 15,000 rubles. mafi tsada fiye da misali.
Ciwon sukari da hauhawar jini zai zama abin da ya wuce
- Normalization na sukari -95%
- Cirewa kan jijiyoyin mara wuya - 70%
- Cire zuciyar mai karfin zuciya -90%
- Rabu da cutar hawan jini - 92%
- Increasearuwar kuzarin rana, inganta bacci da dare -97%
| Aiki | Yana daidaita tsarin metabolism daga bangarori da yawa: yana inganta haɓakar insulin, rage haɓakar glucagon, rage jinkirin ciwan hanji, rage cin abinci, kare farji, jinkirta mutuwar ƙwayoyin beta da kuma haɓaka haɓaka sababbi. Metformin a matsayin wani ɓangare na Galvus Meta yana rage juriya na insulin, yana hana haɗin glucose a cikin hanta da shigar ta daga narkewa. Galvus yana iya inganta bayanin martaba na jini, a hade tare da metformin, ana inganta wannan aikin sosai. Rashin bioavailability na miyagun ƙwayoyi ya kai 85%, ba ya canza dangane da lokacin cin abinci. Dangane da umarnin don amfani, matsakaicin maida hankali akan abu a cikin jini yana faruwa bayan minti 105, idan an ɗauki allunan akan komai a ciki, kuma bayan minti 150, idan tare da abinci. Mafi yawan vildagliptin an kebe su a cikin fitsari, kimanin 15% ta hanyar narkewar abinci, metformin yana cire komai daga ƙodan. |
| Alamu | Type 2 ciwon sukari. Jiyya na Galvus ba ya soke abincin da ilimin jiki. Ana iya amfani dashi azaman wani ɓangare na jiyya mai rikitarwa, ba'a amfani dashi don nau'in 1 na ciwon sukari da ketoacidosis. |
| Contraindications | Tabbataccen contraindication shine rashin lafiyan halayen mahaɗan maganin. Abinda ke ciki na allunan sun hada da lactose, saboda haka ba a ba su shawarar karancin lactase ba. Ba a tsara Galvus ga yara ba, tunda ba a yi nazarin sakamakonsa ga jikin yara ba. Don aiki na yau da kullun, dole ne a sanya Galvus cikin tsari a kan kari kuma a keɓe shi daga jiki. Kafin ka fara shan kwayoyin, marassa lafiya masu ciwon suga da ke fama da hanta da koda koda ya kamata a kara wani gwaji. Har ila yau, an haramta karbar Galvus Meta don rashin ruwa, yawan kumburi, mummunan cututtukan da ke tattare da cutar, matsanancin rikicewar cutar sankara, giya. Allunan na ɗan lokaci an soke yayin aikin tiyata, maye giya, gabatarwar abubuwa na radiopaque. |
| Kula da lafiya | Saboda gaskiyar cewa Galvus na iya shafar aikin hanta, umarnin don amfani yana ba da shawarar cewa yayin gudanarwarsa, ƙarfafa ikon lafiya. Kafin shan kwayoyin, yana da kyau a dauki gwajin hanta: Gwajin jini don AcAt da AlAt. Ana sake maimaita karatun kwata-kwata a farkon shekarar shiga. Idan sakamakon gwajin hanta ya ninka sau uku fiye da na al'ada, dole ne a soke Galvus. Galvus Met yana ƙara haɗarin lactic acidosis. Halin yana haɗuwa da gajeriyar numfashi, jin zafi a cikin tsokoki da ciki, faɗuwa cikin zafin jiki. Marasa lafiya tare da lactic acidosis suna buƙatar asibiti gaggawa. |
| Yankan zaɓi | Kowane kwamfutar hannu Galvus ta ƙunshi 50 mg na vildagliptin. Sha 1 ko 2 Allunan a rana. Yawan yana dogara da tsananin ciwon sukari. Hakanan ana ba da izinin Galvus Met fiye da allunan 2. Har zuwa 1000 MG na metformin an ƙara shi a kowace kwamfutar hannu. Misali, a cikin Galvus Met 50 + 1000 mg: vildagliptin 50, metformin 1000 mg. An zaɓi sashi na metformin gwargwadon glycemia. |
| Yawan damuwa | Excessarin adadin da aka ba da izini na adadin da aka ba da izini yana haifar da edema, zazzabi, jin zafi, da raunin hankali. Doaukar adadin abin sama da ya ninka sau shida yana ƙaruwa da haɓaka abubuwan da ke cikin enzymes da sunadarai a cikin jini. Doaukar adadin Galvus Meta yana da haɗari ga lactic acidosis. Lokacin ɗaukar fiye da 50 g na metformin, rikitarwa yana faruwa a cikin 32% na marasa lafiya. An kula da yawan abin sama da yakamata a alamace, idan ya cancanta, an cire maganin daga jini ta amfani da hemodialysis. |
| Side effects | Galvus yana haifar da ƙarancin halayen m. Yawancin sakamako masu illa suna da laushi da wucin gadi, sabili da haka, baya buƙatar shafe Allunan. Matsaloli masu yuwuwa: <10% na marasa lafiya - tsananin farin ciki, <1% - ciwon kai, maƙarƙashiya, kumburi daga ƙarshen, <0.1% - aikin hanta mai rauni. Statisticsididdigar tasirin sakamako na Galvus Meta, ban da cin zarafin da aka ambata a sama, har ila yau ya haɗa da sakamako mara kyau wanda metformin ya haifar:> 10% - tashin zuciya ko wasu matsalolin narkewa, <0.01% - halayen fata, lactic acidosis, B12 anemia. |
| Ciki da GV | Bayanan gwaji na farko sun nuna cewa Galvus baya tsoma baki tare da ci gaban tayi, amma isassun gogewa game da amfani da maganin bai riga ya tattara ba. Ba a gudanar da bincike kan yiwuwar shigar azzakari cikin vildagliptin cikin madara ba. Sakamakon rashin bayanai koyarwar ta hana amfani da Galvus yayin daukar ciki da ciyarwa. |
| Hulɗa da ƙwayoyi | Babu wasu maganganun ma'amala na vildagliptin tare da wasu kwayoyi. Metformin na iya canza tasiri yayin shan shi tare da kwayoyin, kwayar matsa lamba da sauran mashahuri kwayoyi (ana samun cikakken jerin abubuwa a cikin umarnin). |
| Abun da ke ciki na allunan | Vildagliptin ko vildagliptin + metformin, lactose, cellulose, magnesium stearate, titanium dioxide, talc. |
| Adanawa | Galvus - shekaru 2, Galvus Met - watanni 18. |
Karin Galvus
Metformin magani ne na yau da kullun don ciwon sukari na 2, an wajabta shi ga kusan duk marasa lafiya. Na dogon lokaci na amfani, ba wai kawai an tabbatar da ingancin wannan magani ba, amma har ma an sami sakamako masu amfani da yawa ga zuciya, jijiyoyin jini, jigilar jini. Dangane da shawarar kungiyoyin kwantar da hankali, wasu magunguna ana wajabta su ne kawai lokacin da metformin bai isa ba don rama ciwon sukari.
Allunan Galvus Met suna haɗuwa, sun ƙunshi metformin da vildagliptin. Yin amfani da miyagun ƙwayoyi na iya rage yawan allunan, wanda ke nufin hakan yana rage haɗarin rasa ɗayansu. Rashin kyau na miyagun ƙwayoyi shine mafi girman farashin magani idan aka kwatanta da wani kashi na Galvus da metformin.
| Dosages Galvus Met, mg | Matsakaicin matsakaici don shafin 30, rubles. | Farashin 30 allunan Galvus da Glucofage na kashi ɗaya, rubles. | Farashin farashi,% |
| 50+500 | 1550 | 875 | 44 |
| 50+850 | 890 | 43 | |
| 50+1000 | 950 | 39 |
Analogs da wasu abubuwa
Tun da Galvus sabon magani ne, kariyar patent har yanzu tana kan shi. Sauran masana'antun ba za su iya samar da Allunan tare da kayan aiki guda ɗaya ba, analogues na gida mai arha ba su rayuwa.
DPP-4 inhibitors da incetin mimetics na iya yin aiki azaman maye gurbin Galvus:
- sitagliptin (Januvius, Xelevia, Yasitara);
- saxagliptin (Onglisa);
- Exenatide (Baeta);
- liraglutide (Viktoza, Saksenda).
Duk waɗannan takwarorinsu masu tsada ne, musamman Baeta, Viktoza da Saksenda. Magungunan Rasha kawai na sama shine Yasitar daga Pharmasintez-Tyumen. An yi rajistar maganin a ƙarshen 2017, har yanzu ba a same shi a cikin magunguna ba.
Idan mai haƙuri ya bi abincin, yana ɗaukar Galvus Met a gwargwadon ƙwayar cuta, kuma sukari har yanzu yana sama da al'ada, to, kumburin yana kusa da gajiya. A wannan halin, zakuyi ƙoƙarin kuɓutar da kwayar insulin tare da abubuwan ƙira na sulfonylurea, amma mafi kusantar su, suma zasu zama basu da tasiri sosai. Idan insulin dinka ya daina fitowa, mai ciwon sukari yana buƙatar sakewa da insulin. Kada ku jinkirta farkonsa. Rikici na ciwon sukari yana haɓaka ko da tare da ƙara yawan glucose.
Karfe Galvus ko Yanumet
Duk magungunan suna dauke da wakilai na hypoglycemic daga rukuni guda: Galvus Met - vildagliptin tare da metformin, Janumet - sitagliptin tare da metformin. Dukansu suna da zaɓuɓɓuka iri ɗaya da farashin farashi: Allunan 56 na Yanumet - 2600 rubles, shafin 30. Matan Galvus - 1550 rubles. Tunda suna rage haemoglobin na glycated, ingancin su ana ɗaukar daidai. Wadannan magungunan ana iya kiransu mafi kusa analogues.
Bambancin magunguna:
- Vildagliptin yana inganta bayanin martaba na jini, ta haka ne zai iya rage haɗarin angiopathy, sitagliptin ba wai kawai ba shi da tasirin gaske, amma kuma yana iya haɓaka cholesterol.
- Metformin ba shi da haƙuri da haƙuri, lokacin da aka ɗauka, ana haifar da sakamako masu illa a cikin narkewa. Tsawan nau'in metformin yana taimakawa haɓaka haƙuri. Yana daga cikin katunan Yanumet Long. Galvus Met da Yanumet sun ƙunshi metformin na yau da kullun.
Galvus ko Metformin
A cikin Galvus Mete, abubuwa masu aiki daidai suke. Su duka suna shafar matakan sukari, amma suna aiwatar da ayyukansu daga kusurwoyi mabambanta. Metformin - galibi saboda raguwa a cikin juriya na insulin, vildagliptin - karuwa a cikin aikin insulin. A zahiri, tasiri mai yawa akan matsalar shine mafi inganci. Dangane da sakamakon aunawa, ƙari na Galvus zuwa metformin yana rage haɓakar glycated da 0.6% a cikin watanni 3.
Ba shi da ma'ana a yanke shawara ko Galvus ko metformin ya fi kyau. Ana ɗaukar Metformin a farkon cutar tare da abinci da wasanni, na kwayoyi, Glucofage na asali ko samfurin Siofor ya fi kyau. Lokacin da bai isa ba, an kara Galvus a cikin tsarin kulawa ko kuma a canza metformin Galvus Metomet.
Mai araha mai araha ne ga Galvus
Kwayoyin sunada tsada fiye da Galvus, amma iri ɗaya mai inganci da tasiri ba su wanzu ba tukuna. Kuna iya rage jinkirin ci gaban ciwon sukari tare da horarwa na yau da kullun, abinci mai ƙarancin carb, da metformin mai arha. Mafi kyawun diyya don ciwon sukari, tsawon sauran kwayoyi ba za a buƙata ba.
Sanannun shirye-shiryen sulfonyl urea, kamar Galvus, haɓaka aikin insulin. Waɗannan sun haɗa da ƙarfi, amma ba aminci Maninil, mafi zamani Amaryl da Diabeton MV. Ba za a iya ɗaukarsu analogues na Galvus ba, tunda tsarin aikin kwayoyi ya sha bamban. Abubuwan da aka samo na sulfonylureas suna tsokani hypoglycemia, zubar da fitsari, hanzarta lalata ƙwayoyin beta, don haka lokacin da kuka kwashe su, ya kamata ku kasance cikin shiri don gaskiyar cewa a cikin 'yan shekaru za ku buƙaci maganin insulin. Galvus yana hana mutuwar kwayoyin sel, yana tsawaita aikin farji.
Dokokin shigar da kara
Kwarin da aka ba da shawarar Vildagliptin:
- MG 50 a farkon gudanarwa, lokacin amfani dasu tare da shirye-shiryen sulfonylurea, suna ɗaukar kwamfutar hannu da safe;
- 100 MG don tsananin ciwon sukari mellitus, ciki har da maganin insulin. An rarraba maganin zuwa kashi biyu.
Don metformin, kashi mafi kyau shine 2000 MG, matsakaicin shine 3000 MG.
Galvus na iya bugu akan komai a ciki ko kuma cikakken cikakken ciki, Galvus Met - kawai tare da abinci.
Rage haɗarin sakamako masu illa
A cewar masu ciwon sukari, Galvus Met ana jure dan kadan fiye da tsarkakakkiyar metformin, amma kuma yawanci yana haifar da matsalolin narkewa: zawo, amai, da rashin jin daɗi a ciki. Karyata jiyya tare da irin wannan alamu ba shi da daraja. Don rage tsananin tasirin sakamako, kuna buƙatar ba jiki lokaci don daidaitawa da miyagun ƙwayoyi. Jiyya yana farawa da ƙarancin magani, sannu a hankali yana haɓaka shi zuwa mafi kyau.
Kimanin algorithm don haɓaka kashi:
- Mun sayi fakiti na Galvus Met na ƙananan matakan (50 + 500), mako na farko mun ɗauki kwamfutar hannu 1.
- Idan babu matsalar narkewa, muna canzawa zuwa kashi biyu da safe da maraice. Ba za ku iya sha Galvus Met 50 + 1000 mg ba, duk da irin maganin.
- Lokacin da kunshin ya ƙare, saya 50 + 850 MG, sha Allunan 2.
- Idan sukari har yanzu yana sama da na al'ada, bayan ƙarshen marufi, za mu canza zuwa Galvus Met 50 + 1000 MG. Ba za ku iya ƙara yawan sashi ba kuma.
- Idan biyan diyya ga ciwon sukari bai isa ba, muna ƙara sulfonylurea ko insulin.
An shawarci masu cutar Obese masu ciwon sukari su dauki matsakaicin metformin. A wannan yanayin, da maraice, suna ƙara shan Glucofage ko Siofor 1000 ko 850 mg.
Idan sukari mai azumi yana ɗaukaka, kuma bayan cin abinci mafi yawan lokuta a cikin iyakoki na al'ada, ana iya daidaita magani: sha Galvus sau biyu, da Glucofage Long - sau ɗaya da maraice a sashi na 2000 MG. Extreme Glucofage zai yi aiki da karfi duk daren, don haka tabbatar da al'ada glycemia da safe. Rashin haɗarin hypoglycemia kusan ba ya nan.
Amfani da barasa
A cikin umarnin Galvus, ba a ambaci barasa ba, wanda ke nufin cewa barasa ba ya tasiri da ingancin allunan kuma baya kara tasirin sakamako. Amma lokacin amfani da Galvus Meta, shan giya da barasa suna hana juna aiki, tunda suna haɓaka alama da lactic acidosis. Bugu da ƙari, shan giya na yau da kullun, har ma da adadi kaɗan, ya cutar da diyya na ciwon sukari. Yawancin shan barasa ana ɗaukar saurin hadari idan har yawan maye yana da laushi. A matsakaici, 60 g na giya ne ga mata kuma 90 g na maza ne.
Tasiri akan nauyi
Galvus Met ba shi da tasiri kai tsaye a kan nauyi, amma duka kayan aiki masu aiki a cikin kayanta suna inganta haɓakar mai da rage cin abinci. Dangane da sake dubawa, godiya ga metformin, marasa lafiya masu ciwon sukari na iya rasa poundsan fam. Mafi kyawun sakamako shine ga masu ciwon sukari tare da ɗimbin nauyin wuce kima da ƙoshin insulin.
