Don lura da nau'in mellitus na sukari na 2, ana amfani da kwayoyi waɗanda zasu iya shafar babban dalilin cutar sanƙara (hyperglycemia) - ƙarancin hankali ga insulin. Tun da yawancin marasa lafiya da ke dauke da cutar ta biyu suna da kiba sosai, yana da kyau idan irin wannan ƙwayar za ta iya taimakawa a lokaci guda wajen magance kiba.
Tun da miyagun ƙwayoyi daga rukunin biguanide - metformin (Metfogamma, Glucofage, Siofor, Dianormet) na iya shafar metabolism da mai mai, ana bada shawara a cikin hadaddun jiyya ga masu ciwon sukari haɗe tare da kiba.
A cikin 2017, amfani da magunguna wanda ke dauke da metformin ya cika shekaru 60 da haihuwa, amma har ya zuwa yanzu an sanya shi cikin jerin magunguna don magance cututtukan cututtukan mellitus bisa ga shawarar WHO. Binciken kaddarorin metformin yana haifar da fadada alamomi don amfanin sa.
Glucophage tsarin aikin
An gabatar da miyagun ƙwayoyi Glucofage a cikin magunguna a cikin nau'ikan saki masu zuwa: Glucofage 500, Glucofage 850, Glucofage 1000 da tsayayyen siffofin - Glucofage tsawo. Abubuwan da basu da tabbas na magunguna dangane da metformin sun haɗa da farashin mai araha. Hanyar aiwatar da maganin yana da kyau an fahimta.
Tushenta shine tasirin da aka samu akan samarda sabon kwayoyin sikari a cikin hanta. A cikin ciwon sukari na mellitus, ana ƙaruwa da wannan tsari sau 3 idan aka kwatanta da na yau da kullun. Glucophage ta kunna yawancin enzymes da ke hana gluconeogenesis.
Bugu da ƙari, marasa lafiya tare da glucofage suna kara yawan jijiyar kyallen takarda zuwa insulin (galibi ƙwayar tsoka). Magungunan yana haɓaka haɗin insulin da masu karɓa a cikin sel jini, hepatocytes, sel mai, myocytes, yana ƙaruwa da yawan shigar azzakari cikin su da kuma kama shi daga jini.
Rage samuwar glucose a cikin hanta yana haifar da raguwa a cikin yawan glycemia na azumi, da kuma hana karuwar carbohydrate a cikin lumen karamin hanji yana rage girman hauhawar hawan jini bayan cin abinci. Glucophage yana da mallakin rage girman hancin ciki da kuma motsa motsin karamin hanji.
A lokaci guda, hadawan abu na hada-hadar kitse na rage kiba, cholesterolemia, matakin triglycerides da atherogenic lipids suna raguwa. Duk waɗannan tasirin zasu iya faruwa ne kawai a gaban insulin a cikin jini.
Sakamakon magani na Glucofage, an lura da sakamako masu zuwa:
- Rage cikin glycemia da 20%, helylobin glycated da 1.54%.
- Rashin haɗarin infarbarewa na mace-macen jini, yawan mace-mace yana raguwa.
- Lokacin da aka sanya shi zuwa mataki na ciwon suga, masu ciwon sukari mellitus na faruwa sau da yawa.
- Increara yawan tsammanin rayuwa da rage haɗarin ciwace-ciwacen ciwacen daji (bayanan gwaji).
Glucophage yana fara aiki tsakanin sa'o'i 1-3, kuma tsayayyen siffofin (Glucophage tsawon) 4-8 hours. Ana lura da ingantaccen sakamako na kwanaki 2-3. An lura cewa ilimin tsufa na metformin ba ya haifar da hare-haren hypoglycemic, tun da yake ba ya rage sukarin jini kai tsaye, amma yana hana karuwa.
Glucophage shine asalin maganin metformin, saboda haka ana amfani dasu yayin bincike. An tabbatar da tasirin Glucophage akan sarrafa nau'in ciwon sukari na 2 na 2, da raguwa cikin haɗarin haɓaka rikicewar cutar, musamman daga tsarin zuciya.
Glucophage don ciwon sukari na 2
Babban mahimmancin amfani da miyagun ƙwayoyi shine nau'in ciwon sukari na 2 a hade tare da kiba, ƙwayar cholesterol a cikin jini, daidai da nauyin jiki na al'ada. Wasu marasa lafiya da ciwon sukari ba su yarda da shirye-shiryen sulfonylurea ba, ko kuma su sami juriya a kansu, Glucofage zai iya taimakawa wannan rukuni na marasa lafiya.
Hakanan, ana iya ba da shawarar metformin don maganin haɗin gwiwa tare da insulin don ciwon sukari na 1, da kuma a cikin haɗuwa daban-daban tare da kwayoyi don rage sukari a cikin allunan don ciwon sukari na 2.
Na zaɓi adadin Glucophage daban-daban, a ƙarƙashin kulawar glycemia na yau da kullun. Singleaya daga cikin kashi shine 500-850 MG, kuma kullun kashi shine 2.5-3 g. Dosearancin amfani ga yawancin marasa lafiya shine 2-2.25 g.
Jiyya yana farawa da karamin kashi - 500 MG kowace rana, idan ya cancanta, ƙaruwa da 500 MG tare da tazara tsakanin kwanaki 7. Yawan allurai (fiye da 3 g) baya haifar da ci gaba a cikin tsarin glucose.Yawancin lokaci, ana daukar glucophage sau 2-3 a rana.
Don hana tasirin sakamako daga hanji, ana bada shawarar a sha magani lokacin ko bayan abinci.
Wajibi ne a la'akari da daidaituwa na Glucophage, wanda sauran magunguna masu rage sukari basu mallaka - ikon hana haɓakar saurin glucose da hanta. Don yin amfani da wannan keɓaɓɓen aikin zuwa matsakaicin, kuna buƙatar ɗaukar glucophage kafin lokacin kwanciya.
Inganta tafiyar matakai na rayuwa ya bayyana kanta bayan kwanaki 7-10, kuma yawan tattarawar sukari na jini ya fara raguwa da kwanaki 2. Bayan an biya diyya na hyperglycemia kuma an kiyaye shi sosai, zaku iya ƙoƙarin rage ƙananan ƙwayar a hankali a ƙarƙashin kulawa da sukari na jini akai-akai.
Ana amfani da haɗarin magungunan masu zuwa:
- Glucophage + Glibenclamide: suna da hanyoyi daban-daban na tasirin tasiri kan cutar glycemia, inganta tasirin juna.
- Glucophage + Insulin: an rage buƙatar insulin zuwa 25-50% na asali, dyslipidemia da matsa lamba ana daidaita su.
Yawancin karatu na ciwon sukari mellitus suna ba mu damar kammalawa cewa jurewar insulin yana fara haɓakawa a cikin marasa lafiya tun da wuri. Sabili da haka, ana bada shawarar yin amfani da Glucofage a cikin kashi na 1 g kowace rana, tare da abinci da aikin jiki.
Ana aiwatar da irin wannan prophylaxis a cikin marasa lafiya tare da kiba, rage haƙuri na carbohydrate, cholesterol mai yawa, hauhawar jini da kuma yanayin gado game da ciwon sukari na 2.
Glucophage yana taimakawa wajen shawo kan juriya na insulin kuma yana rage abubuwan da suka wuce kima a cikin jini, yana hana lalacewar jijiyoyin jiki.
Glucophage tare da ƙwayar polycystic
Kwayoyin polycystic da juriya na insulin ana bayyanasu ta hanyar karuwar matakan maza na jima'i, tsawaita lokacin haila da rashin haihuwa, wanda ke haifar da irin wannan mara lafiyar ga rashin haihuwa.
Mata suna yawan yin kiba da cututtukan ƙwayar jijiyoyin ƙwayoyin cuta na polycystic, suna da illa ga haƙuri ko kuma tabbatar da ciwon sukari na mellitus. Amfani da Glucophage a cikin hadaddun jiyya na irin wannan mara lafiyar yana inganta aikin haihuwa, a lokaci guda yana haifar da asarar nauyi da daidaituwar yanayin hormonal.
Yin amfani da Glucofage a cikin kashi na 1500 MG kowace rana na tsawon watanni shida ya rage matakin insulin a cikin jini, an sake dawo da haila a kusan kashi 70% na mata.
A lokaci guda, an lura da sakamako mai kyau akan abubuwan da ke cikin jini: raguwa a cikin ƙwayoyin cholesterol da ƙarancin lipoproteins mai yawa.
Tasirin glucophage akan nauyi
Kodayake kwayoyi da suka danganta da metformin ba su da wata alama ta kai tsaye don amfani da kiba, ana amfani dasu don rage nauyi, musamman idan akwai cin zarafin ƙwayoyin carbohydrate. Game da sake duba Glucofage na rasa nauyi, duka tabbatacce kuma yana tabbatar da ƙarancin ingancinsa.
Irin wannan ra'ayoyi daban-daban - "Na rasa nauyi akan Glyukofage kuma na rasa kilo 6," "Ba na rasa nauyi, duk da yawan allurai," "kawai Glyukofage ya taimaka wajen rasa nauyi," "Da farko na rasa nauyi akan Glyukofage, sannan nauyin ya tsaya", "Kawi 1 kilo kawai cikin wata daya. ", nuna cewa wannan magungunan bazai taimaki kowa ba.
Babban kayan magungunan, wanda ke taimakawa asarar nauyi, shine karuwa ga hankalin insulin, wanda ke haifar da raguwa cikin matsanancin ƙwayar cuta, tunda ba a buƙatar ƙarin adadi don shawo kan juriya na mai karɓa. Irin wannan raguwar insulin a cikin jini yana haifar da rage kiba mai yawa kuma yana haɓaka aikinta.
Kari akan haka, tasirin Glucofage yana bayyana kansa akan yadda ake jin yunwar, yana rage ci, da hanawa shan sinadarin carbohydrates a cikin hanji da kuma hanzarta kawar dasu saboda karuwar yawan jiki yayin da ake cikin abinci yana rage adadin adadin kuzari da ake samu.
Tunda Glucophage baya haifar da raguwar sukari na jini a ƙasa da al'ada, yin amfani da shi yana yiwuwa tare da matakin al'ada na glycemia, wato, a mataki na ƙarancin ƙwayar glucose a cikin farkon rikicewar ƙwayoyin carbohydrate da mai mai.
Domin bazai sami damuwa na rayuwa tare da asarar nauyi ba, kuna buƙatar la'akari yayin ɗaukar Glucofage ko Glucofage mai tsawo:
- Shan magungunan baya bada garantin asarar nauyi.
- Ingancin inganci don asarar nauyi a cikin take hakkin haƙuri ga carbohydrates da hyperinsulinemia.
- Dole ne ku bi cin abinci.
- Kada ya kasance akwai carbohydrates mai sauri a cikin abincin.
- An zaɓi kashi ɗaya akayi daban-daban - matakin farko shine 500 MG sau ɗaya a rana.
- Idan zawo ya kamu bayan gudanar da mulki, wannan yana nuna cewa akwai carbohydrates da yawa a cikin abincin.
- Idan tashin zuciya ya faru, rage kashi kaɗan.
Bodybuilders suna amfani da metformin tare da horarwa ta iska don ƙona kitse. Tsawon lokacin wannan karatun shine kwanaki 20, bayan wannan kuna buƙatar hutu tsawon wata ɗaya. Duk wani amfani da miyagun ƙwayoyi an haramta shi sosai ba tare da izinin likita ba.
Don haka, zamu iya yanke shawara cewa nadin Glucofage zai iya zama tabbatacce a cikin lura da marasa lafiya da ke fama da matsanancin narkewar ƙwayar narkewar ƙwayar cuta, wanda ke tattare da babban matakin insulin a cikin jini da juriya na hanta, tsoka da mai kitse a ciki.
Normalization na tafiyar matakai na rayuwa yana haifar da asarar nauyi, yana ƙarƙashin ƙuntatawa na abinci da isasshen aikin jiki. Ba'a nuna magungunan don maganin kiba ba tare da bincike na farko ba.
A lokuta da yawa, asarar nauyi shine sakaci, kuma haɗarin damuwa na damuwa yana da yawa.
Sakamakon sakamako na glucophage da cutar da lafiyar
Yawancin sakamako masu illa ga Glucophage sune tashin hankali, tashin hankali a cikin bakin, gudawa, ciwon hanji, tashin zuciya, tashin zuciya. Irin waɗannan sakamako mara kyau na shan miyagun ƙwayoyi halaye ne na farkon kwanakin amfani da Glucophage, sannan su wuce kansu, ba tare da ƙarin magani ba.
Tare da tsananin zawo, an soke maganin. Bayan jiki yayi amfani dashi, tasirin metformin akan hanjinsa baya raguwa. Tare da karuwa a hankali a kashi, ana iya gujewa rashin jin daɗi.
Amfani da Glucophage na dogon lokaci yana haifar da bayyanar cututtuka na B12 hypovitaminosis: rauni na ƙwaƙwalwar ajiya, rashin damuwa, tashin hankali na bacci. Hakanan yana yiwuwa ci gaban anemia a cikin ciwon sukari.
Don rigakafin, ana bada shawara don shan bitamin a cikin darussan kowane wata, musamman tare da salon cin ganyayyaki kawai.
Babban mummunan sakamako na rukunin biguanide, wanda kawai metformin ake amfani dashi, shine haɓakar lactic acidosis. Saboda haɗarin ci gabanta ne yasa aka janye sauran magungunan wannan rukunin daga kasuwar magunguna. Wannan rikitarwa ya faru ne saboda gaskiyar cewa ana amfani da lactate wajen aiwatar da samuwar glucose a cikin hanta, kuma metformin yana hana wannan hanyar juyawa.
A lokacin aikin koda, al'ada mai yawa na lactate an keɓe shi, amma tare da yawan amfani da giya, gazawar zuciya, cututtukan tsarin huhu ko lalacewar koda, lactic acid ya tara, wanda ke haifar da irin waɗannan bayyanar:
- Ciwon ciki
- Jin zafi a ciki da bayan sternum.
- Ciwon ciki
- Rashin numfashi.
- Rashin tausayi da nutsuwa.
A cikin lokuta masu tsauri, lactic acidosis na iya haifar da coma. Bugu da kari, Glucophage yana rage matakin horar da tsotsar jini ta tsotsa, kuma a cikin maza - testosterone.
Metformin yana contraindicated a cikin cututtuka na kodan, hanta da huhu, barasa da rauni mai rauni, ketoacidosis, matsanancin rikice-rikice na ciwon sukari mellitus a cikin hanyar hyperosmolar ko lactic acidosis coma.
Ba a sanya magungunan don rage yawan kalori (a ƙalla 1000 kcal a kowace rana), bushewar jiki, bayan shekaru 60, tare da ƙwaƙƙwaran ƙwaƙwalwar jiki, har ma lokacin ciki da lactation.
Dr. Kovalkov daga bidiyo a wannan labarin zai yi magana game da fa'idodin Glucophage ga mutane masu kiba.
