Acorta magani ne wanda ke cikin rukunin magunguna da ake kira statins. Mafi sau da yawa, likitoci suna ba da shi ga mutanen da ke fama da cutar atherosclerosis da kowane cuta na rashin lafiyar lipid a jiki. Ana samun wannan maganin ta hanyar kananan allunan a cikin wani fim na fim. Launi na allunan na iya kasancewa a tsakanin dukkan tabarau masu ruwan hoda. Suna da zagaye da siffa, convex a garesu, kuma idan suka karye a ciki, su fari ne ko beige.
Babban kayan aiki na Akorta shine rosuvastatin. Hakanan, ban da rosuvastatin, abubuwan da ke cikin miyagun ƙwayoyi sun haɗa da abubuwa masu taimako kamar lactose, cellulose, alli, magnesium, crospovidone. Fim ɗin fim ɗin allunan da kansa ya ƙunshi lactose, hypromellose, titanium dioxide, triacetin da fenti a cikin ɗaukar baƙin ƙarfe. Dukkanin Allunan suna cikin daidaitattun marufi na guda 10.
Hanyar aiwatar da aikin acorta
Akorta, ko kuma akasin haka, babban sashi mai aiki, rosuvastatin, takamaiman mai hana mai enzyme ne na musamman - hydroxymethylglutaryl-coenzyme reduar sauyawa, wanda a cikin taƙaitaccen tsari zai yi kama da HMG-CoA. HMG-CoA ingantaccen enzyme ne mai mahimmanci wanda ke da alhakin canza hydroxy-3-methylglutaryl-coenzyme A zuwa wani abu da ake kira mevalonate, ko mevalonic acid.
Mevalonate hanya ce ta kai tsaye zuwa ga cholesterol, wuce haddi wanda shine babban hadarin kamuwa da cutar atherosclerosis. Halin ƙwayar cholesterol da rushewar lipoproteins mai yawa (LDL) yana faruwa a cikin hanta. Daga nan ana iya faɗi tare da daidaito cewa hanta ita ce babbar maƙasudin aikin miyagun ƙwayoyi.
Magungunan suna taimakawa wajen kara yawan masu karba don karancin lipoproteins mai yawa a saman kwayoyin halittun hanta, hakan yana haifar da karuwa sosai a yayin kama kayayyakinsu na lalata, kuma kayan lipoproteins kyauta basa shiga cikin jini. Bugu da ƙari, a cikin hanta, wani rukuni na lipoproteins kuma an haɗa shi - ƙarancin ƙima sosai (VLDL). Akorta ce ke hana tasirinsu aiki kuma yana haifar da raguwa a matakinsu a cikin jinin mutum.
Rosuvastatin yana taimakawa rage yawan kumburi lipoprotein low, sosai, kuma a lokaci guda yana ƙara matakin "mai kyau" cholesterol - daga HDL. Yawan adadin cholesterol, apolipoproteins B (amma, bi da bi, yana ƙaruwa da haɗuwa da apolipoproteins A), triglycerides kuma yana raguwa sosai, matakin "atherogenic" cholesterol an rage shi gaba ɗaya.
Wannan hanyar aiwatar da aiki tana bayyana babban tasirin maganin - ragewan lipid (a zahiri - rage yawan kitse). Wannan sakamako kai tsaye ya dogara da adadin maganin da likitan halartar ya tsara. Don cimma maganin warkewa, watau, ingantaccen sakamako mai tasiri, yana da buƙatar ɗaukar magani don mako guda. Don samun matsakaicin, "girgiza" sakamakon, yana ɗaukar aƙalla makonni huɗu na cin abinci na yau da kullun da kuma ƙarin ci gaba na kashi da tsari.
Aikace-aikacen Akorta yana da kyau tare da alƙawarin magunguna daga rukunin magunguna na ƙwararrun lipid wanda ake kira fibrates, har ma da nicotinic acid, wanda ke taimakawa haɓaka matakin babban lipoproteins mai yawa.
Pharmacokinetics da pharmacodynamics Acorta
Pharmacokinetics shine abin da ke faruwa tare da ƙwayar kanta a jikin mutumin da ya sha. Sakamakon gaggawa shine kawai 20% na kashi da aka karɓa. Wannan sabon abu ana kiran shi bioavailability. Wannan adadin magungunan ne da wuya ya kai inda ya kamata. Mafi girman taro na Acorta ana lura da sa'o'i 3-5 bayan gudanar da maganin baka. Bai kamata ku sha magungunan kashe abinci tare da abinci ba, kamar yadda kowane abinci yake taimakawa rage yawan ƙwayoyi. Rosuvastatin daidai ya shiga cikin shinge na hematoplacental, wanda yakamata a yi la’akari da shi lokacin da yake rubuta wannan magani ga mata masu juna biyu.
Lokacin da aorta ya shiga jikin mu, galibi yakan shafi hanta, kuma ana amfani dashi ta hanyar, yana haifar da ma'anar sinadarin cholesterol da ƙarancin mai yawa. Hakanan, rosuvastatin yana da alaƙa da furotin jini. A cikin metabolism, wato musayar rosuvastatin, enzymes hepatic suna aiki sosai, mafi yawa - cytochrome P-450, wanda shine ɗayan manyan abubuwan da ke ba da aikin aiwatar da numfashi na nama.
Cirewa, ko kawarwa, shine babban kashi na miyagun ƙwayoyi yana faruwa ta hanyar narkewa, shine ta hanjin hanji. Theananan da ragowar kashi an cire su da ƙodan. Ragewa a cikin maida hankali ga miyagun ƙwayoyi a cikin jini da rabi ana kiransa rabin rai. Rabin rayuwar Acorta sa'o'i goma sha tara ne, kuma ba shi da 'yanci.
Hanyar metabolism na rosuvastatin ba ta canzawa ta kowace hanya kuma ba ya dogara da shekaru da jinsi na marasa lafiya ba, amma ya dogara ne da kasancewar abubuwan haɗuwa da cututtukan ƙwayoyin cuta kamar na koda da gaɓar hanta. A cikin marasa lafiya da ke fama da mummunan lalacewa na koda, yawan haɗuwa da miyagun ƙwayoyi a cikin jini ya ninka sau uku fiye da mutane masu lafiya. Kuma a cikin marasa lafiya da gazawar hanta, an lura da karuwa a cikin rabin rayuwar rosuvastatin.
Hakanan, metabolism da sakamako na Acorta ya dogara da lahani na kwayoyin ko kawai bambance-bambance.
Umarnin don amfani da miyagun ƙwayoyi
An wajabta Aorta don cututtuka daban-daban na metabolism na lipid.
Babban nuni shine kasancewar atherosclerosis.
Ana amfani da miyagun ƙwayoyi azaman ƙari ga abincin don rage ƙwayar cholesterol da ƙananan kuzarin mai yawa.
Baya ga wannan, an wajabta magunguna:
- A matsayin ƙarin prophylactic na cututtuka na tsarin zuciya da jijiyoyin jini a cikin marasa lafiya ba tare da alamun asibiti na cututtukan zuciya na zuciya ba. Waɗannan sun haɗa da infarction myocardial, bugun jini, hauhawar jini. A wannan yanayin, shekarun marasa lafiya yana da mahimmanci - ga maza sun girmi shekaru 50, kuma ga mata - sama da 60. Hakanan ya cancanci la’akari da ƙarancin babban adadin ƙwayar lipoprotein cholesterol da kasancewar cututtukan zuciya na zuciya a cikin dangi na kusa;
- Primary hypercholesterolemia bisa ga Fredricksen ko wani nau'in haɗakarwa shine haɓakar cholesterol ba tare da wani dalili na waje ba. An tsara miyagun ƙwayoyi a matsayin ƙarin kayan aiki, musamman idan wasu kwayoyi, abinci da aikin jiki bai isa ba don cimma tasirin da ake so;
- Nau'i na huɗu na hypertriglyceridemia bisa ga Fredricksen a matsayin ƙarin matakin haɗin gwiwa tare da ilimin abinci.
Contraindications don amfani da Akorty sun dogara da yawan ƙwayoyi. Don maganin yau da kullun na 10 zuwa 20 MG, halayen rashin lafiyan cuta sune contraindications; mummunan cututtukan hanta ko na kullum a cikin matsanancin mataki, wanda a cikin nazarin kwayoyin halittar jini an ayyana shi azaman ninki uku a cikin samfuran hanta idan aka kwatanta da alamu na yau da kullun; mai rauni na koda. takamaiman zafin jiki na sukari na madara (lactose), rashi ko cin zarafin hanyoyin sha; kasancewar a cikin tarihin ciwon kai (rauni na tsoka); na lokaci mai gudana na wani magani wanda ake kira cyclosporin; tsinkayen kwayoyin halittar ci gaban cutar kansa; lokacin daukar ciki da lactation a cikin mata; karamin shekaru.
Lokacin da dosing Akorta 40 MG kowace rana, yakamata a ƙara contraindications masu zuwa cikin contraindications na sama:
- Rashin ƙwayar thyroid - hypothyroidism;
- Kasancewa a cikin tarihin mutum ko na gaba na dangi na cututtukan ƙwayar tsoka;
- Haɓaka aikin myotoxicity lokacin shan kwayoyi tare da madaidaicin tsarin aikin aiki;
- Yawan shan barasa
- Duk wani yanayi wanda zai haifar da karuwa a cikin rosuvastatin a cikin jiki;
- Marasa lafiya na tseren Mongoloid;
- Dukanta amfani da fibrates;
Bugu da kari, contraindication shine kasancewar a jikin mai haƙuri na tsananin tsananin matsalar rashin aiki na koda.
Fasali na amfanin acorta a cikin wasu hanyoyin
Tare da matsanancin taka tsantsan, ya kamata a ba da umarnin Akorta a cikin sashi na 10 da 20 a cikin ƙwayar cuta a gaban wasu maganganun haɗin kai a cikin jikin mutum.
Ya kamata a kula da hankali lokacin amfani da magani idan akwai haɗarin cututtuka na tsarin tsoka
Bugu da ƙari, ya kamata a kiyaye marasa lafiya da suke shan wannan magani a ƙarƙashin kulawa ta musamman a gaban kashin koda na kowane mataki a jikin mai haƙuri.
Kari akan haka, yakamata ayi amfani da inganci da taka tsantsan idan an gano mara lafiyar:
- ƙarancin ƙwayar cutar ƙwayar cuta;
- kasancewar cikin tarihin mutum ko na gaba na dangi na cututtukan ƙwayar tsoka;
- ci gaban myotoxicity lokacin shan kwayoyi tare da kama daidai da aikin aiwatarwa;
- yawan shan barasa;
- kowane yanayi wanda zai haifar da karuwa a cikin rosuvastatin a cikin jiki;
- tsufa - fiye da shekaru 65;
- cututtukan hanta na baya;
- rauni na kwance;
- rage matsin lamba;
- mahimman hanyoyin aikin tiyata da aka yi a baya;
- raunin rauni;
- rikicewar rayuwa, daidaitawar ruwa-electrolyte, matakan hormonal;
- ba a kame ba.
Don sashi na 40 MG a rana, ƙuntatawa sun kusan iri ɗaya:
- Tsufa - fiye da shekaru 65;
- Cutar cutar hanta da ta gabata;
- Cutar kuturta;
- Rage matsin lamba;
- Manyan hanyoyin aikin tiyata a baya;
- Raunin raunin da ya faru;
- Rashin daidaituwa na narkewa, daidaitawar ruwa-electrolyte, matakan hormonal;
- Kwayar cuta mara kyau;
- Matsakaici gazawar.
Hakanan ya kamata a yi amfani da hankali lokacin amfani da miyagun ƙwayoyi don bi da mutane na tseren Mongoloid kuma tare da hadaddun amfani da fibrates.
Yawan tasirin sakamako lokacin shan Acorta yana dogara ne akan kashi.
Sakamakon sakamako na iya faruwa daga tsarin jiki daban-daban.
Tsarin jijiya - jin zafi a kai, jin damuwa, raɗaɗi tare da jijiyoyi, ƙarancin ji na ciki, asarar ƙwaƙwalwa.
Gastrointestinal tract - take hakkin motsi, tashin zuciya, ciwon ciki, kumburi da farji, cututtukan narkewa, hanji, tasirin mai guba a hanta.
Tsarin numfashi - kumburi da hanji, kumburin hanci, sinuses, bronchi, huhu, fuka, gazawar numfashi, tari.
Tsarin zuciya - angina pectoris (matsi mai zafi a bayan sternum), hauhawar jini, jan fata, jin bugun zuciya.
Tsarin tsoka - jin zafi a cikin tsokoki, gidajen abinci, kumburi tare, jijiyoyin jijiyoyin wuya, rhabdomyolysis.
Bayyanar bayyanar cututtuka - fatar fata, itching, rashes a cikin bayyananniyar jan blisters (urticaria), kumburi da fata, Stevens-Johnson syndrome - mafi rashin lafiyar rashin lafiyar.
Canje-canje a cikin binciken - karuwa a cikin sukari na jini, bilirubin, samfuran hanta, creatine phosphokinase.
Sauran: nau'in ciwon sukari na 2 na cututtukan zuciya, bayyanar cututtuka, rashin taushin nono, ƙarancin ƙwayar platelet, ƙonewa, haɓaka nono a cikin maza.
Game da yawan abin sama da ya kamata, an lura da karuwar halayen masu illa. Don hana shi, yakamata a bi umarnin sosai.
Farashin Akorta a Rasha ya tashi daga 500 zuwa 550 rubles, don haka ana ɗaukar magungunan da ɗan arha. Analogues na Akorta sun haɗa da magunguna irin su Krestor, Rosuvastatin, Roxer, Tevastor, Fastrong, da magungunan cikin gida ba su da ƙarancin tasiri. Nazarin game da amfanin Akorta galibi tabbatacce ne.
Ana ba da bayani game da gumaka a cikin bidiyon a cikin wannan labarin.
