Don maganin ciwon sukari, ana amfani da insulin mutum da analogues. Masu masana'antar NovoRapid Flexpen suna ba da irin wannan magani a cikin kayan da aka shirya don gudanarwa.
Sunan kasa da kasa mai zaman kansa
Insulin kewayawa
Masu kera NovoRapid Flexpen suna ba da irin wannan magani a cikin kayan da aka shirya don gudanarwar insulin.
ATX
A10AB05 asparagine na insulin
Saki siffofin da abun da ke ciki
An samar da maganin ta hanyar maganin shayarwa mai narkewa tare da taro na 100 U / ml (35 μg a 1 U). Kamar yadda aka kara abubuwan taimako:
- salts na acid na sodium;
- hydrochloric acid da zinc da sodium salts;
- cakuda glycerol, phenol, metacresol;
- sodium hydroxide.
Akwai shi a cikin allon alkalami guda 3, guda 5 a cikin kowane kwali.
Aikin magunguna
Magungunan yana rage matakin ƙwayar cuta, saboda Yana hulɗa a hankali tare da takamaiman ligands-insulin-ins a cikin membranes cell. Sakamakon haka, aka samar da hadaddun insulin-receptor, wanda yake haifar da hanyoyin yin amfani da glucose din jini:
- karuwar sha daga sel;
- fashewar kwayar kwantar da hankali a cikin tasirin glucose sakamakon aiki na samarda kwayoyin pyruvate kinase da enzymes hexokinase;
- kira na mai kitse kyauta daga glucose;
- karuwa a cikin shagunan glycogen ta amfani da glycogen synthase enzyme;
- kunnawa hanyoyin aiwatarwa;
- hanawa na gluconeogenesis.
Magungunan yana rage matakin ƙwayar cuta, saboda Yana hulɗa a hankali tare da takamaiman ligands-insulin-ins a cikin membranes cell.
Pharmacokinetics
Bayan allura a karkashin fata, ana amfani da insulin aspart cikin sauri zuwa cikin jini, yana fara aikinsa a matsakaici a cikin mintina 15, aikin mafi girma yana faruwa ne a cikin mintuna 60-180. Mafi girman lokacin tasirin hypoglycemic shine 5 hours.
Ga mutanen da suka haura shekaru 65 ko tare da rage yawan aikin hanta, raguwar ƙimar shaƙa halayyar ne, wanda aka bayyana a cikin jinkiri a lokacin farawa mafi girma.
Gajeru ko tsayi
Halittar kwayoyin halitta na kwayar halitta ta mutum ya banbanta ta tsarin kwayar halitta ta B28: maimakon proline, an gina acid aspartic a cikin abun da ke ciki. Wannan fasalin yana haɓaka ɗaukar mafita daga mai mai ƙananan ƙwaƙwalwa idan aka kwatanta da insulin ɗan adam, saboda ba ya samuwa a cikin ruwa mai kama da shi a hankali yana lalata ƙungiyoyi na kwayoyin 6. Bugu da kari, sakamakon canje-canjen sune kaddarorin wadannan magungunan da suka bambanta da kwayar halittar jikin mutum:
- farkon fara aiki;
- mafi girman tasirin hypoglycemic a farkon sa'o'i 4 bayan cin abinci;
- gajeren lokacin tasirin hypoglycemic.
Da aka ba waɗannan halaye, ƙwayar tana cikin rukunin insulins tare da aikin ultrashort.
Ana amfani da magani don daidaita al'ada da sarrafa bayanan martaba a cikin nau'in 1 na ciwon sukari.
Alamu don amfani
Ana amfani da magani don daidaita al'ada da sarrafa bayanan martaba a cikin nau'in 1 na ciwon sukari. Ana amfani da wannan manufar ta hanyar sanya maganin don maganin cutar cuta ta 2. Amma da wuya a bada shawarar fara warkarwa. Dalilan gabatarwar insulin a cikin tsarin magani na nau'in ciwon sukari na 2 sune kamar haka:
- karancin sakamako ko rashinsa daga cututtukan cututtukan zuciya don sarrafa bakin;
- yanayin da ke haifar da lalacewa ta wucin gadi ko na dindindin yayin cutar sankarar cuta (kamuwa da cuta, guba, da sauransu).
Contraindications
An yarda da maganin don amfani a cikin dukkanin kungiyoyin shekaru, ban da farkon watanni 24 na rayuwa. An sanya magani cikin haɓakar halayen rashin haƙuri gare shi ko tarihin da ya dace. Yana da haɗari don gudanarwa idan akwai yanayin rashin lafiyar hypoglycemia.
Tare da kulawa
Babban haɗarin faɗuwar sukari cikin jini yayin farji yana faruwa a cikin marasa lafiya:
- shan kwayoyi waɗanda ke hana narkewa;
- fama da cututtukan da ke haifar da raguwa a malabsorption;
- tare da nakasa hanta da aikin koda.
Kula da hankali game da glycemia da abubuwan sarrafawa ya zama dole ga marasa lafiya:
- sama da shekara 65;
- a karkashin shekara 18;
- tare da cutar kwakwalwa ko rage aiki na hankali.
Yadda za a yi amfani da NovoRapid Flexpen?
Cartarfin andaukar maganin da sikelin ragowar suna a ƙarshen ƙarshen naúrar, kuma mai jigilar kaya da fuloti akan ɗayan. Wasu sassa na tsarin suna lalacewa cikin sauƙi, saboda haka ya zama dole a bincika amincin kowane ɓangarorin kafin amfani. Abubuwan da aka buƙata tare da tsawon mm 8 tare da sunayen kasuwanci NovoFayn da NovoTvist sun dace da na'urar. Zaka iya shafa saman abin rike da auduga swab cikin soyayyen ethanol, amma ba a yarda nutsuwa cikin ruwa ba.
Umarnin ya hada da wadannan hanyoyin gudanarwa:
- a karkashin fata (injections kuma ta hanyar famfo don ci gaba da jiko);
- jiko cikin jijiyoyi.
Ga na ƙarshen, dole ne a tsarma magani ga taro na 1 U / ml ko lessasa.
Yadda ake yin allura?
Karka sanya allurar ruwa mai sanyi. Don tsarin kulawa da yanki, irin su:
- bango na ciki;
- saman kafada;
- yankin cinya na gaban kansa;
- babba fili na waje na gluteal yankin.
Dabaru da dokoki don yin allura tare da kowane amfani:
- Karanta sunan maganin a kan filastik. Cire murfin daga kicin.
- Fitar da sabon allura, kafin cire fim din daga ciki. Cire ƙofofin waje da na ciki daga allura.
- Kira akan mai rarraba 2 raka'a. Riƙe sirinji tare da allura sama, matsa a kan kwalin a sauƙaƙe. Latsa maɓallin ɗauka - a kan mai watsa, mai nunawa ya kamata ya motsa zuwa sifili. Wannan zai taimaka hana iska shiga cikin nama. Idan ya cancanta, maimaita gwajin har sau 6, rashin sakamakon yana nuna rashin aikin na na'urar.
- Gujewa danna maɓallin ɗauka, zaɓi kashi. Idan sauran suka rage, to ba za'a iya nuna adadin da ake buƙata ba.
- Zaɓi wurin yin allurar daban da na baya. Ansu rubuce-rubucen fata tare da kitsen mai ƙanƙara, gujewa kama tsokoki na ciki.
- Saka allura cikin crease. Latsa maɓallin ɗauka a ƙasa zuwa alamar "0" akan mai raba. Bar allura a karkashin fata. Bayan ƙidaya 6 seconds, sami allura.
- Ba tare da cire allura daga sirinji ba, saka ragowar hula ta waje mai kariya (ba ciki!). Sai a kwance kuma a watsar.
- Rufe murfin katako daga na'urar.
Don gudanarwa na ƙarƙashin ƙasa, yankuna kamar babban faren waje na gluteal yankin ana ɗauka mafi dacewa.
Ciwon sukari
Kafin farawa tare da gajeren insulin, ana bada shawara ga mara lafiyar ya shiga makarantar mai fama da cutar siga don koyon yadda ake lissafin abubuwan da ake buƙata da kuma tantance alamun cututtukan hypo-da hyperglycemia a kan kari. Ana sarrafa hormone na gajere lokaci-lokaci kafin abinci ko kuma nan da nan bayan.
Matsakaicin insulin don karin kumallo, abincin rana da abincin dare za a iya ba da shawarar ta likita a cikin ƙayyadaddun lambobi ko ƙididdigar marasa lafiya suna yin la'akari da glycemia kafin cin abinci. Ko da irin yanayin da aka zaɓa, mai haƙuri dole ne ya koya don saka idanu kan alamu na glucose da kansa.
Hannun magani na ɗan gajeren lokaci yana haɗuwa da yawan amfani da kwayoyi don sarrafa matakan basal na glucose na jini, wanda ya rufe daga 30 zuwa 50% na yawan buƙatar insulin. Matsakaicin matsakaita na yau da kullun na gajeren magani shine 0.5-1.0 U / kg ga mutanen da ke cikin nau'ikan shekaru daban-daban.
Guidelinesa'idodin ka'idoji don tantance ma'aunin yau da kullun ta 1 kg na nauyi:
- nau'in cuta 1 / bincikar lafiya ta farko / ba tare da rikitarwa da lalata ba - raka'a 0.5;
- lokacin cutar ya wuce shekara 1 - raka'a 0.6;
- saukar wahalar cutar - raka'a 0.7;
- ɓarna cikin sharuddan glycemia da glycated haemoglobin - raka'a 0.8;
- ketoacidosis - raka'a 0.9;
- gestation - 1.0 raka'a.
Sakamakon sakamako na NovoRapida Flexpen
Abubuwan da ba a so don amfani da su sun yi kama da waɗanda suke don hormone na huhu, amma yawan jini a cikin dare ba ya da yawa.
Daga tsarin rigakafi
A cikin mafi yawan lokuta, bayyanuwar cutar anaphylaxis:
- tashin hankali, rawar jiki;
- tachycardia;
- bronchospasm, gajeriyar numfashi;
- zawo, amai;
- Kushin rubutun Quincke.
Vomiting shine ɗayan cututtukan sakamako na miyagun ƙwayoyi.
A bangaren metabolism da abinci mai gina jiki
Rage yiwuwar glucose din plasma, wanda yawancin lokuta yakan yi bayyaninsa ta hanyar fara kwatsam kuma a asibiti ya bayyana ta bayyanar cututtuka masu zuwa:
- fatar jiki, sanyi, rigar, clammy zuwa taɓawa;
- tachycardia, hauhawar jini;
- tashin zuciya, yunwa;
- raguwa da tashin hankali na gani;
- Canje-canje na ƙwaƙwalwar ƙwaƙwalwa daga rauni gaba ɗaya tare da tashin hankali na psychomotor (juyayi, rawar jiki a cikin jiki) don kammala ɓacin rai na hankali da tashin hankali.
Tsarin juyayi na tsakiya
Bayyanar cututtukan gefe suna haɓaka da asalin cututtukan cututtukan zuciya kuma ana nuna su ta bayyanar cututtuka masu zuwa:
- ciwon kai
- Dizziness
- nutsuwa
- rashin tsaro a tsaye da zaune;
- disorientation a sararin samaniya da kan lokaci;
- rage ko raunana sani.
Tare da babban saurin sakamako na bayanin martaba na glycemic na al'ada, an lura da farfadowar jinƙai mai lalacewa na zuciya.
Daga gefen tsarin juyayi na tsakiya, ciwon kai na iya faruwa.
A wani bangare na bangaren hangen nesa
Ba kasafai aka sami rahoton matsalar rashin lafiyan cuta ba. Babban nasarar da aka samu na sarrafa kwayar cutar glycemic shine ya haifar da rikicewa yayin ciwan cututtukan ciwon sukari, wanda ya tsaya tare da yin jinkiri tare da kara warkewa.
A ɓangaren fata
Halin da ake ciki na yanki na gudanar da aikin ƙarƙashin ƙasa ko alamun rashin haƙuri yana yiwuwa: furuci, jan launi, ƙaiƙayi, ƙashin gida, urticaria.
Cutar Al'aura
Bayyanar bayyanar rashin haƙuri ana ɗaukar halayen fata da halayen anaphylactic.
Tasiri kan ikon sarrafa abubuwan inji
Dangane da yiwuwar gurɓataccen aiki na kwakwalwa da rikicewar gani akan asalin cutar sanƙarau, dole ne a yi taka tsantsan yayin sarrafa hanyoyin motsawa da aikata nau'ikan haɗari.
Umarni na musamman
Ana buƙatar buƙata gyaran fuska:
- lokacin juyawa daga wani hormone;
- canza abinci
- cutuka.
Dangane da yiwuwar lalatawar kwakwalwa da hargitsi na gani akan asalin cutar sikila, dole ne a kula lokacin da ake sarrafa hanyoyin motsi.
Yi amfani da lokacin daukar ciki da lactation
A cikin binciken da aka gudanar tare da halartar mata masu juna biyu da masu shayarwa, ba a sami sakamako mara kyau ga tayin da yaro ba. Dokar ne aka yanke ta hanyar likita. An gano halaye masu zuwa:
- Makonni 0-13 - ana rage buƙatar homoniya;
- 14-40 mako - karuwa cikin buƙata.
Amfani da barasa
Ba a bada shawarar wannan haɗin ba, saboda sakamakon aikace-aikacen ba a iya faɗi shi ba: yana iya kasancewa duka rashin aikin ne akan matakin glucose da raguwar wuce gona da iri a cikin ƙwayar jini.
Yawan adadin NovoRapida Flexpen
A allurar maganin a cikin allurai wanda ya wuce bukatun jikin mutum, alamomin cututtukan hawan jini. Mutumin da yake da sani zai iya ba da taimakon farko ta kashin kansa ta hanyar ɗaukar samfurin carbohydrate mai sauƙin narkewa. Idan babu hankali, ana gudanar da glucagon a karkashin fata ko tsokoki a cikin kashi na 0.5-1.0 mg ko glucose na ciki.
Yin hulɗa tare da wasu kwayoyi
Insara insulin zuwa maganin kwantar da hankali na ƙwayar cuta na iya haifar da raguwa mai yawa a cikin glycemia. Wasu magungunan antimicrobial da antiparasitic suna da sakamako iri ɗaya: tetracyclines, sulfnilamides, ketoconazole, mebendazole.
A cikin binciken da aka yi tare da mata masu juna biyu, ba a sami sakamako masu illa a tayin da yaran ba.
A cikin aikin kula da cututtukan zuciya, ana yin la'akari da cewa beta-blockers na iya ɓoye asibiti na hypoglycemia, kuma masu hana tashar alli da clonidine suna rage tasirin maganin.
Lokacin da ake kulawa da magungunan psychotropic, ƙarin sa ido sosai ya zama dole, saboda magunguna kamar su monoamine oxidase inhibitors, magungunan da ke dauke da lithium, bromocriptine na iya haɓaka tasirin hypoglycemic, da kuma maganin tricyclic antidepressants da morphine, akasin haka, za a iya rage su.
Yin amfani da rigakafin hana haihuwa, cututtukan hodar iblis, hanji, adrenal glandon, hormone girma yana rage halayyar masu karban magani ko kuma tasirinsa.
Octreotide da lanreotide suna haifar da hypo- da hyperglycemia a fagen aikin insulin.
Abubuwa masu dauke da abubuwa masu dauke da sinadarai masu dauke da sinadarai masu dauke da sinadarai wadanda suke lalata insulin din.
Don haɗuwa a cikin tsarin guda ɗaya, isofan-insulin kawai, maganin sodium chloride bayani, 5 ko 10% dextrose bayani (tare da abun ciki na 40 mmol / l potassium chloride) an yarda.
Analogs
Magani tare da maganin insulin wanda ke cikin NovoRapid Penfill. Don kudaden da za a iya gwadawa a cikin tsawon lokacin da lokacin farawa sun haɗa da:
- Humalogue;
- Apidra.
Magunguna kan bar sharuɗan
Da takardar sayan magani.
Zan iya saya ba tare da takardar sayan magani ba?
A'a, saboda samfurin yana da tsayayyen alamu don dalilin. Ba za su sayar da maganin ga mutanen da ba su cika shekara 18 ba.
Ana fitar da maganin daga kantin magani tare da takardar sayan magani.
Farashi don NovoRapid Flexpen
Daga 1,606.88 rub. har zuwa 1865 rub. don shiryawa.
Yanayin ajiya na miyagun ƙwayoyi
Ana amfani da na'urar da ake amfani da sauyawa a zazzabi a ɗakin. Katun katako daga hasken rana kai tsaye ta hanyar sanya hula mai kariya. A karkashin irin wannan yanayin ajiya, rayuwar shiryayye yana iyakance ga wata 1.
Hanyoyin da ba a amfani dasu tare da bayani dole ne a adana su a zazzabi + 2 ... + 8 ° C. Kar a daskare.
Ranar karewa
Shekaru 2.5.
Mai masana'anta
Novo Nordisk (Denmark).
Ra'ayoyi game da NovoRapida Flexpen
Likitoci
Irina S., likitan dabbobi, Moscow
Yin amfani da gajere da tsinkayyar insulins ya sauƙaƙa ikon sarrafa glycemic. Kuna iya zaɓar yanayi ɗaya wanda ke inganta yanayin rayuwar mai haƙuri, yayin da yake hana ci gaba da cutar.
Gennady T., therapist, St. Petersburg
Masu ciwon sukari suna ɗaukar magani tare da su. Thearfin gudanarwa ba tare da tazara tsakanin abinci ba ya sauƙaƙa wa marasa lafiya damar shirya rana. Zai fi dacewa kuma mafi aminci don amfani da shirye-shirye dangane da kwayar mutum.
Marasa lafiya
Elena, 54 shekara, Dubna
Na yi amfani da wannan magani tsawon shekaru 2. Yawancin fa'idodi: allura kawai, basa jin ciwo. An yarda da abun da ke ciki
Pavel, shekara 35, Novosibirsk
An canza maganin ta fiye da watanni 6 da suka gabata, nan da nan an lura da wani aiki mai sauri. Jiyya yana da tasiri: haemoglobin mai narkewa yana ƙasa low.
